2024
Platelet–Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease
Zhang Y, Jia C, Guo M, Chen Q, Wen Y, Wang T, Xie Y, Fan X, Gao J, Yarovinsky T, Liu R, Jiang Z, Wang M, Zhou J, Che D, Fu L, Edelson R, Gu X, Hwa J, Tang W. Platelet–Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease. Advanced Science 2024, e2406282. PMID: 39665236, DOI: 10.1002/advs.202406282.Peer-Reviewed Original ResearchKawasaki diseaseCD14<sup>+</sup>CD16<sup>+</sup> monocytesPlatelet-monocyte aggregatesAberrant immune responseAcute febrile illnessCoronary artery aneurysmsNuclear factor-kappaBSystemic vasculitisPlatelet-monocyteProinflammatory monocytesPlatelet hyperreactivityArtery aneurysmVasculopathyFebrile illnessCytokine mediatorsHyperactive plateletsReduce inflammationPlatelet glycoproteinImmune responseInterleukin-1Platelet activationPositive feedback loopLigand 1MonocytesGrowth factor
2020
Reduced Platelet miR-223 Induction in Kawasaki Disease Leads to Severe Coronary Artery Pathology Through a miR-223/PDGFRβ Vascular Smooth Muscle Cell Axis
Zhang Y, Wang Y, Zhang L, Xia L, Zheng M, Zeng Z, Liu Y, Yarovinsky T, Ostriker AC, Fan X, Weng K, Su M, Huang P, Martin KA, Hwa J, Tang WH. Reduced Platelet miR-223 Induction in Kawasaki Disease Leads to Severe Coronary Artery Pathology Through a miR-223/PDGFRβ Vascular Smooth Muscle Cell Axis. Circulation Research 2020, 127: 855-873. PMID: 32597702, PMCID: PMC7486265, DOI: 10.1161/circresaha.120.316951.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAnimalsBlood PlateletsCase-Control StudiesCells, CulturedChildChild, PreschoolCoronary Artery DiseaseCoronary VesselsDisease Models, AnimalFemaleHumansInfantMaleMice, Inbred C57BLMice, KnockoutMicroRNAsMucocutaneous Lymph Node SyndromeMuscle, Smooth, VascularMyocytes, Smooth MusclePlatelet ActivationProspective StudiesReceptor, Platelet-Derived Growth Factor betaSeverity of Illness IndexSignal TransductionYoung AdultConceptsSevere coronary pathologyCoronary artery pathologyKawasaki diseaseCoronary pathologyArtery pathologyMiR-223Medial damageHealthy controlsVSMC dedifferentiationHallmark of KDMiR-223 knockout miceVascular smooth muscle cell dedifferentiationSmooth muscle cell dedifferentiationPlatelet miR-223Platelet-derived miRNAsVSMC differentiationMedial elastic fibersMiR-223 levelsMuscle cell dedifferentiationPotential therapeutic strategyInhibitor imatinib mesylateVascular smooth muscle cell phenotypeSmooth muscle cell phenotypeMiR-223 mimicsUptake of platelets