Thomas Eugene Zapadka
he/him/his
About
Research
Publications
2025
Restoring compromised blood-retina-barrier integrity with Netrin-1 overexpression
Furtado J, Zapadka T, Park H, Boyé K, Demb J, Eichmann A. Restoring compromised blood-retina-barrier integrity with Netrin-1 overexpression. Cellular And Molecular Life Sciences 2025, 82: 389. PMID: 41196411, PMCID: PMC12592616, DOI: 10.1007/s00018-025-05903-6.Peer-Reviewed Original ResearchDietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling
Wing A, Jeffery E, Church C, Goodell J, Saavedra-Peña R, Saha M, Holtrup B, Voisin M, Alavi N, Floody M, Wang Z, Zapadka T, Garabedian M, Varshney R, Rudolph M, Rodeheffer M. Dietary oleic acid drives obesogenic adipogenesis via modulation of LXRα signaling. Cell Reports 2025, 44: 115527. PMID: 40208790, PMCID: PMC12073628, DOI: 10.1016/j.celrep.2025.115527.Peer-Reviewed Original ResearchOptic nerve injury impairs intrinsic mechanisms underlying electrical activity in a resilient retinal ganglion cell
Zapadka T, Tran N, Demb J. Optic nerve injury impairs intrinsic mechanisms underlying electrical activity in a resilient retinal ganglion cell. The Journal Of Physiology 2025, 603: 6623-6652. PMID: 39985791, PMCID: PMC12353978, DOI: 10.1113/jp286414.Peer-Reviewed Original ResearchMolecular Components of Vesicle Cycling at the Rod Photoreceptor Ribbon Synapse
Hanke-Gogokhia C, Zapadka T, Finkelstein S, Arshavsky V, Demb J. Molecular Components of Vesicle Cycling at the Rod Photoreceptor Ribbon Synapse. Advances In Experimental Medicine And Biology 2025, 1468: 325-330. PMID: 39930217, DOI: 10.1007/978-3-031-76550-6_54.Chapters
2024
Specific retinal neurons regulate context-dependent defensive responses to visual threat
Lee T, Weinberg-Wolf H, Zapadka T, Rudenko A, Demb J, Kim I. Specific retinal neurons regulate context-dependent defensive responses to visual threat. PNAS Nexus 2024, 3: pgae423. PMID: 39359403, PMCID: PMC11443969, DOI: 10.1093/pnasnexus/pgae423.Peer-Reviewed Original ResearchThe Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3
Hanke-Gogokhia C, Zapadka T, Finkelstein S, Klingeborn M, Maugel T, Singer J, Arshavsky V, Demb J. The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3. Journal Of Neuroscience 2024, 44: e1379232024. PMID: 38641407, PMCID: PMC11209669, DOI: 10.1523/jneurosci.1379-23.2024.Peer-Reviewed Original Research
2023
IL-17A Enhances Retinal Neovascularization
Taylor B, Lee C, Zapadka T, Zhou A, Barber K, Taylor Z, Howell S, Taylor P. IL-17A Enhances Retinal Neovascularization. International Journal Of Molecular Sciences 2023, 24: 1747. PMID: 36675261, PMCID: PMC9866094, DOI: 10.3390/ijms24021747.Peer-Reviewed Original Research
2022
Inhibition of CD40-TRAF6-dependent inflammatory activity halts the onset of diabetic retinopathy in streptozotocin-diabetic mice
Howell S, Lee C, Zapadka T, Lindstrom S, Taylor B, Taylor Z, Barber K, Taylor P. Inhibition of CD40-TRAF6-dependent inflammatory activity halts the onset of diabetic retinopathy in streptozotocin-diabetic mice. Nutrition & Diabetes 2022, 12: 46. PMID: 36309487, PMCID: PMC9617859, DOI: 10.1038/s41387-022-00225-z.Peer-Reviewed Original Research
2021
Retinal Inflammation, Oxidative Stress, and Vascular Impairment Is Ablated in Diabetic Mice Receiving XMD8-92 Treatment
Howell S, Lee C, Batoki J, Zapadka T, Lindstrom S, Taylor B, Taylor P. Retinal Inflammation, Oxidative Stress, and Vascular Impairment Is Ablated in Diabetic Mice Receiving XMD8-92 Treatment. Frontiers In Pharmacology 2021, 12: 732630. PMID: 34456740, PMCID: PMC8385489, DOI: 10.3389/fphar.2021.732630.Peer-Reviewed Original ResearchAryl Hydrocarbon Receptor Agonist VAF347 Impedes Retinal Pathogenesis in Diabetic Mice
Zapadka T, Lindstrom S, Batoki J, Lee C, Taylor B, Howell S, Taylor P. Aryl Hydrocarbon Receptor Agonist VAF347 Impedes Retinal Pathogenesis in Diabetic Mice. International Journal Of Molecular Sciences 2021, 22: 4335. PMID: 33919327, PMCID: PMC8122442, DOI: 10.3390/ijms22094335.Peer-Reviewed Original Research