2022
Collective behavior and nongenetic inheritance allow bacterial populations to adapt to changing environments
Mattingly H, Emonet T. Collective behavior and nongenetic inheritance allow bacterial populations to adapt to changing environments. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2117377119. PMID: 35727978, PMCID: PMC9245662, DOI: 10.1073/pnas.2117377119.Peer-Reviewed Original ResearchConceptsNongenetic inheritanceCollective migrationPhenotype compositionIsogenic populationsDifferential lossSwimming phenotypeCell divisionBacterial populationsCell growthMultiple environmentsPhenotypePhenotypic compositionDifferent phenotypesInheritanceChemotactic bacteriaModel systemHigh inheritanceMigration speedDifferent environmentsNew environmentCollective behaviorMigrationPopulationGrowthDiversity
2020
Adaptive tuning of cell sensory diversity without changes in gene expression
Kamino K, Keegstra JM, Long J, Emonet T, Shimizu TS. Adaptive tuning of cell sensory diversity without changes in gene expression. Science Advances 2020, 6: eabc1087. PMID: 33188019, PMCID: PMC7673753, DOI: 10.1126/sciadv.abc1087.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalBacterial ProteinsChemotaxisEscherichia coliEscherichia coli ProteinsGene ExpressionConceptsPhenotypic diversityGene expressionCell variationDiversity of phenotypesChemoreceptor TarPosttranslational modificationsAllosteric couplingEnvironmental cuesChemotaxis networkCovalent modificationEnvironmental changesDiversitySensory diversityCell populationsCellsExpressionSuch betsPhenotypeEscherichiaPopulationPrevious studiesModificationVariationSignalsChemoreceptors
2019
Front-end Weber-Fechner gain control enhances the fidelity of combinatorial odor coding
Kadakia N, Emonet T. Front-end Weber-Fechner gain control enhances the fidelity of combinatorial odor coding. ELife 2019, 8: e45293. PMID: 31251174, PMCID: PMC6609331, DOI: 10.7554/elife.45293.Peer-Reviewed Original ResearchAdaptation, PhysiologicalAnimalsDrosophilaMushroom BodiesOlfactory PerceptionReceptors, OdorantSmell
2014
Adaptability of non-genetic diversity in bacterial chemotaxis
Frankel NW, Pontius W, Dufour YS, Long J, Hernandez-Nunez L, Emonet T. Adaptability of non-genetic diversity in bacterial chemotaxis. ELife 2014, 3: e03526. PMID: 25279698, PMCID: PMC4210811, DOI: 10.7554/elife.03526.Peer-Reviewed Original ResearchConceptsGene regulationNon-genetic diversityBacterial chemotaxis systemHeritable controlChemotaxis systemSelectable traitAdvantageous diversityEnvironmental variationBacterial chemotaxisEnvironmental variabilityClonal populationsDiverse environmentsDiversityE. coliProtein levelsMutationsDifferent environmentsRegulationForagingTraitsColiDiversificationBacteriaColonizationPopulation
2013
Adaptation Dynamics in Densely Clustered Chemoreceptors
Pontius W, Sneddon MW, Emonet T. Adaptation Dynamics in Densely Clustered Chemoreceptors. PLOS Computational Biology 2013, 9: e1003230. PMID: 24068908, PMCID: PMC3777915, DOI: 10.1371/journal.pcbi.1003230.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalChemoreceptor CellsChemotaxisEscherichia coliKineticsMethylationModels, TheoreticalConceptsOrganisms senseChemotaxis pathwayTransmembrane receptorsNutrient gradientsReceptor methylationProtein abundanceReceptor substrateBacterial chemotaxisReceptor activityModification systemPathway constituentsEscherichia coliIndividual cellsEnvironmental stimuliFunctional robustnessExpression levelsMechanistic relationshipEnzymeModel systemEnzyme kineticsChemotaxis systemPrecise adaptationAdaptation dynamicsReceptor modificationModification kineticsIntensity Invariant Dynamics and Odor-Specific Latencies in Olfactory Receptor Neuron Response
Martelli C, Carlson JR, Emonet T. Intensity Invariant Dynamics and Odor-Specific Latencies in Olfactory Receptor Neuron Response. Journal Of Neuroscience 2013, 33: 6285-6297. PMID: 23575828, PMCID: PMC3678969, DOI: 10.1523/jneurosci.0426-12.2013.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAdaptation, PhysiologicalAnimalsDrosophilaModels, StatisticalOdorantsOlfactory Receptor NeuronsReaction TimeReceptors, Odorant
2004
From molecular noise to behavioural variability in a single bacterium
Korobkova E, Emonet T, Vilar JM, Shimizu TS, Cluzel P. From molecular noise to behavioural variability in a single bacterium. Nature 2004, 428: 574-578. PMID: 15058306, DOI: 10.1038/nature02404.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalCells, ImmobilizedChemotaxisEscherichia coliFlagellaMethyltransferasesModels, BiologicalSignal TransductionTime FactorsConceptsChemotaxis networkSingle-cell levelSignal transductionPopulation measurementsIntracellular networksMolecular noiseBehavioral variationMolecular eventsBiological complexityIndividual bacteriaNon-stimulated cellsEscherichia coliBehavioral variabilitySingle bacteriumTemporal fluctuationsStatistical fluctuationsTransductionSuch variabilityTemporal variationBacteriumColiGeneral understandingCertain propertiesBacteriaPathway