Risk factors for recurrent tuberculosis after successful treatment in a high burden setting: a cohort study
Cudahy PGT, Wilson D, Cohen T. Risk factors for recurrent tuberculosis after successful treatment in a high burden setting: a cohort study. BMC Infectious Diseases 2020, 20: 789. PMID: 33097000, PMCID: PMC7585300, DOI: 10.1186/s12879-020-05515-4.Peer-Reviewed Original ResearchConceptsM. tuberculosis infectionRecurrent tuberculosisSuccessful treatmentTuberculosis recurrenceHazard ratioSmear gradeTuberculosis infectionRisk factorsSmear-positive pulmonary tuberculosisCox proportional hazards modelSputum smear gradeRepetitive unit-variable number tandem repeat (MIRU-VNTR) typingHigh-burden settingsRisk of recurrenceProportional hazards modelSuccessful treatment completionRecurrent diseaseCohort studyPulmonary tuberculosisBurden settingsClinical presentationRecurrent episodesInitial episodeNumber tandem repeat typingTreatment completionThe risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis
Martinez L, Cords O, Horsburgh C, Andrews J, Consortium P, Acuna-Villaorduna C, Ahuja S, Altet N, Augusto O, Baliashvili D, Basu S, Becerra M, Bonnet M, Boom W, Borgdorff M, Boulahbal F, Carvalho A, Cayla J, Chakhaia T, Chan P, Cohen T, Croda J, Datta S, del Corral H, Denholm J, Dietze R, Dobler C, Donkor S, Egere U, Ellner J, Espinal M, Evans C, Fang C, Fielding K, Fox G, García L, García-Basteiro A, Geis S, Graham S, Grandjean L, Hannoun D, Hatherill M, Hauri A, Hesseling A, Hill P, Huang L, Huerga H, Hussain R, Jarlsberg L, Jones-López E, Kato S, Kato-Maeda M, Kampmann B, Kirchner H, Kritski A, Lange C, Lee C, Lee L, Lee M, Lemos A, Lienhardt C, Ling D, Liu Q, Lo N, Long R, Lopez-Varela E, Lu P, Magee M, Malone L, Mandalakas A, Martinson N, Mazahir R, Murray M, Netto E, Otero L, Parsonnet J, Reingold A, Schaaf H, Seddon J, Sharma S, Singh J, Singh S, Sloot R, Sotgiu G, Stein C, Iqbal N, Triasih R, Trieu L, van der Loeff M, Van der Stuyft P, van Schalkwyk C, Vashishtha R, Verhagen L, Villalba J, Wang J, Whalen C, Yoshiyama T, Zar H, Zellweger J, Zhu L. The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis. The Lancet 2020, 395: 973-984. PMID: 32199484, PMCID: PMC7289654, DOI: 10.1016/s0140-6736(20)30166-5.Peer-Reviewed Original ResearchConceptsYears of agePreventive therapyIncident tuberculosisTuberculosis infectionHazard ratioTuberculosis casesMixed-effects Poisson regression modelsSystematic reviewFinal analysisClose exposureIncident tuberculosis casesRisk of tuberculosisDevelopment of tuberculosisEMBASE electronic databasesIndividual participant dataPositive resultsPoisson regression modelsWeb of ScienceMixed-effects logistic modelBCG vaccinationCohort studyBaseline visitPrevalent tuberculosisContact investigationProspective study