HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice.
Holloway T, Moreno JL, González-Maeso J. HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice. Journal Of Visualized Experiments 2016 PMID: 27501227, PMCID: PMC4993366, DOI: 10.3791/53717.Peer-Reviewed Original ResearchConceptsHead-twitch responseLysergic acid diethylamideBehavioral effectsHead-twitch behaviorSchizophrenia-related behaviorsCortical pyramidal neuronsPowerful translational toolReceptor complexBehavioral phenotypesPyramidal neuronsFrontal cortexReceptor-dependent signaling pathwaysMouse modelHallucinogen DOIHeteromeric receptor complexesTranslational toolBehavioral responsesVirus constructsAcid diethylamideGPCR heteromersBehavioral functionsMiceHallucinogenic drugsSignaling pathwaysCortex