2016
HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice.
Holloway T, Moreno JL, González-Maeso J. HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice. Journal Of Visualized Experiments 2016 PMID: 27501227, PMCID: PMC4993366, DOI: 10.3791/53717.Peer-Reviewed Original ResearchConceptsHead-twitch responseLysergic acid diethylamideBehavioral effectsHead-twitch behaviorSchizophrenia-related behaviorsCortical pyramidal neuronsPowerful translational toolReceptor complexBehavioral phenotypesPyramidal neuronsFrontal cortexReceptor-dependent signaling pathwaysMouse modelHallucinogen DOIHeteromeric receptor complexesTranslational toolBehavioral responsesVirus constructsAcid diethylamideGPCR heteromersBehavioral functionsMiceHallucinogenic drugsSignaling pathwaysCortex
2012
Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice
Moreno JL, Holloway T, Umali A, Rayannavar V, Sealfon SC, González-Maeso J. Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice. Psychopharmacology 2012, 225: 217-226. PMID: 22842765, PMCID: PMC3552490, DOI: 10.1007/s00213-012-2809-7.Peer-Reviewed Original ResearchConceptsChronic clozapineLysergic acid diethylamideAtypical antipsychotic drug actionHead-twitch behaviorC-fosAntipsychotic-like activityAntipsychotic drug actionTherapeutic-like effectsMouse somatosensory cortexSchizophrenia-like behavioral alterationsEgr-2Egr-1Chronic haloperidolChronic treatmentClozapine administrationDrug therapyOptimal treatmentSomatosensory cortexSingle administrationAntipsychotic drugsMurine modelMouse modelRodent modelsSerotonin 5Behavioral alterations
2011
Maternal Influenza Viral Infection Causes Schizophrenia-Like Alterations of 5-HT2A and mGlu2 Receptors in the Adult Offspring
Moreno JL, Kurita M, Holloway T, López J, Cadagan R, Martínez-Sobrido L, García-Sastre A, González-Maeso J. Maternal Influenza Viral Infection Causes Schizophrenia-Like Alterations of 5-HT2A and mGlu2 Receptors in the Adult Offspring. Journal Of Neuroscience 2011, 31: 1863-1872. PMID: 21289196, PMCID: PMC3037097, DOI: 10.1523/jneurosci.4230-10.2011.Peer-Reviewed Original ResearchMeSH KeywordsAdult ChildrenAnimalsAntipsychotic AgentsCerebral CortexDisease Models, AnimalDown-RegulationEarly Growth Response Protein 1Early Growth Response Protein 2FemaleFrontal LobeGlutamic AcidHallucinogensInfluenza A Virus, H1N1 SubtypeMaternal-Fetal ExchangeMiceNeural PathwaysOrthomyxoviridae InfectionsPregnancyProto-Oncogene Proteins c-fosReceptor, Serotonin, 5-HT2AReceptors, Metabotropic GlutamateSchizophreniaUp-RegulationConceptsInfluenza viral infectionViral infectionMouse modelAdult offspringSchizophrenia-like alterationsPrenatal viral infectionHead-twitch responseSchizophrenia-like psychosisInfluenza A/WSN/33 virusMetabotropic glutamate receptorsAntipsychotic-like effectsPrevention of schizophreniaSpontaneous locomotor activityHigher c-fosEffects of hallucinogensBehavioral changesEgr-2 expressionEtiology of schizophreniaMechanism of actionMaternal infectionInfected mothersMaternal exposureGlutamate agonistsAntipsychotic drugsGlutamate system