Featured Publications
Prenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System
Holloway T, Moreno JL, Umali A, Rayannavar V, Hodes GE, Russo SJ, González-Maeso J. Prenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System. Journal Of Neuroscience 2013, 33: 1088-1098. PMID: 23325246, PMCID: PMC3711555, DOI: 10.1523/jneurosci.2331-12.2013.Peer-Reviewed Original ResearchConceptsMetabotropic glutamate 2 receptorPrenatal stressSevere adverse life eventsSchizophrenia-like alterationsMaternal immune systemHead-twitch responsePrenatal immune activationAntipsychotic-like effectsAntipsychotic drug developmentMGlu2/3 agonist LY379268Risk of schizophreniaAdverse life eventsCross-fostering studyEarly neurodevelopmental originHallucinogenic 5Serotonin 2AAgonist DOIImmune activationAgonist LY379268Pathophysiological hypothesesFrontal cortexPsychiatric disordersAdult offspringSerotonin 5Behavioral alterations
2013
Chronic treatment with LY341495 decreases 5-HT2A receptor binding and hallucinogenic effects of LSD in mice
Moreno JL, Holloway T, Rayannavar V, Sealfon SC, González-Maeso J. Chronic treatment with LY341495 decreases 5-HT2A receptor binding and hallucinogenic effects of LSD in mice. Neuroscience Letters 2013, 536: 69-73. PMID: 23333599, PMCID: PMC3578056, DOI: 10.1016/j.neulet.2012.12.053.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsAnimalsDrug AntagonismEarly Growth Response Protein 1Early Growth Response Protein 2HallucinogensLysergic Acid DiethylamideMaleMiceMice, KnockoutProto-Oncogene Proteins c-fosRadioligand AssayReceptor, Serotonin, 5-HT2AReceptors, Metabotropic GlutamateSomatosensory CortexStereotyped BehaviorXanthenesConceptsLysergic acid diethylamideChronic treatmentHallucinogenic drugsHallucinogenic effectsHead-twitch behaviorHallucinogenic 5MGlu2 receptorLast injectionSomatosensory cortexLY341495Serotonin 5Receptor bindingAcid diethylamideC-fosReceptor ligandsMiceDrugsTreatmentEgr-2Egr-1ReceptorsBehavioral responsesKnockoutHigh affinityMetabotropic
2012
Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function*
Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuéllar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, López-Giménez JF, Meana JJ, Benson DL, González-Maeso J. Identification of Three Residues Essential for 5-Hydroxytryptamine 2A-Metabotropic Glutamate 2 (5-HT2A·mGlu2) Receptor Heteromerization and Its Psychoactive Behavioral Function*. Journal Of Biological Chemistry 2012, 287: 44301-44319. PMID: 23129762, PMCID: PMC3531745, DOI: 10.1074/jbc.m112.413161.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmino Acid MotifsAmino Acid SequenceAmino Acid SubstitutionAnimalsBehaviorCase-Control StudiesDimerizationFemaleHumansMaleMiceMice, 129 StrainMice, KnockoutMiddle AgedMolecular Sequence DataProtein BindingReceptor, Serotonin, 5-HT2AReceptors, Metabotropic GlutamateSchizophreniaSchizophrenic PsychologySequence AlignmentYoung AdultConceptsFrontal cortexMetabotropic glutamate 2 receptorGPCR heteromersBehavioral functionsMouse frontal cortexPsychosis-like effectsHallucinogenic 5Receptor neurotransmissionSchizophrenic subjectsReceptor heteromerizationReceptor complex formationSerotoninCortexHeteromeric expressionReceptorsReceptor heterocomplexDomain fourHeteromeric complexesCell signalingThree residuesHeteromersIntracellular endNeurotransmissionAgonistsMice
2011
Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists
Moreno JL, Holloway T, Albizu L, Sealfon SC, González-Maeso J. Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists. Neuroscience Letters 2011, 493: 76-79. PMID: 21276828, PMCID: PMC3064746, DOI: 10.1016/j.neulet.2011.01.046.Peer-Reviewed Original ResearchConceptsLysergic acid diethylamideHallucinogen DOIBehavioral effectsHead-twitch behaviorC-fosEgr-2Hallucinogenic 5MGlu2 receptorReceptor agonistKnockout miceHigh-affinity binding sitesNeuropsychological responsesMiceAgonistsAcid diethylamideHallucinogenic drugsSignaling pathwaysCellular signaling pathwaysReceptorsFunctional interactionMembrane preparationsBehavioral responsesResponseWild typeSerotonin