2012
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, Horvath TL, Sinclair DA, Pfluger PT, Tschöp MH. Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism. Physiological Reviews 2012, 92: 1479-1514. PMID: 22811431, PMCID: PMC3746174, DOI: 10.1152/physrev.00022.2011.Peer-Reviewed Original ResearchConceptsSirtuin 1Sirtuin 3Nonalcoholic fatty liver diseaseMammalian sirtuin 1Multiple metabolic benefitsFatty liver diseaseDiet-induced obesityType 2 diabetesActivation of sirtuinsLiver diseaseCellular energy storesMetabolic benefitsMetabolic disordersPharmacological meansEnergy homeostasisPhysiological modulatorDependent deacetylasesMetabolic processesSirtuinsCellular energy homeostasisEnergy storesCellular sensorsEnergy statusAnabolic processesCatabolic process
2008
Type 3 Deiodinase in Hypoxia: To Cool or to Kill?
Diano S, Horvath TL. Type 3 Deiodinase in Hypoxia: To Cool or to Kill? Cell Metabolism 2008, 7: 363-364. PMID: 18460327, DOI: 10.1016/j.cmet.2008.04.008.Peer-Reviewed Original Research
2007
Enhanced Leptin-Stimulated Pi3k Activation in the CNS Promotes White Adipose Tissue Transdifferentiation
Plum L, Rother E, Münzberg H, Wunderlich FT, Morgan DA, Hampel B, Shanabrough M, Janoschek R, Könner AC, Alber J, Suzuki A, Krone W, Horvath TL, Rahmouni K, Brüning JC. Enhanced Leptin-Stimulated Pi3k Activation in the CNS Promotes White Adipose Tissue Transdifferentiation. Cell Metabolism 2007, 6: 431-445. PMID: 18054313, DOI: 10.1016/j.cmet.2007.10.012.Peer-Reviewed Original ResearchConceptsWhite adipose tissueSympathetic nerve activityBrown adipose tissuePI3k activationAdipose tissueLeptin-deficient ob/obOb/ob miceUnaltered body weightEnergy expenditureOb/obLeptin-sensitive neuronsNerve activityEndogenous leptinOb miceBody weightUCP1 expressionWAT morphologyEnergy homeostasisLeptinSkeletal muscleMicePTEN ablationSignaling pathwaysMitochondrial contentDirect genetic evidence
2002
ER-X: A Novel, Plasma Membrane-Associated, Putative Estrogen Receptor That Is Regulated during Development and after Ischemic Brain Injury
Toran-Allerand CD, Guan X, MacLusky NJ, Horvath TL, Diano S, Singh M, Connolly ES, Nethrapalli S, Tinnikov AA. ER-X: A Novel, Plasma Membrane-Associated, Putative Estrogen Receptor That Is Regulated during Development and after Ischemic Brain Injury. Journal Of Neuroscience 2002, 22: 8391-8401. PMID: 12351713, PMCID: PMC6757764, DOI: 10.1523/jneurosci.22-19-08391.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveBlotting, WesternBrain IschemiaCaveolaeCell MembraneCell-Free SystemCells, CulturedCholesterolEnzyme ActivationEstradiolGene Expression Regulation, DevelopmentalIonophoresMiceMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein KinasesNeocortexNeuronsReceptors, EstrogenRNA, MessengerSignal TransductionSubcellular FractionsSubstrate SpecificityConceptsMAPK cascadePlasma membraneExtracellular signal-regulated kinases ERK1Neuronal differentiationPlasma membrane-associatedPlasma membrane-associated ERsProtein kinase isoformsCell-free systemMembrane-associated ERER alphaPutative ERKinases ERK1Cell divisionER betaSustained phosphorylationKinase isoformsERK activationMembrane-associatedGene-disrupted miceNovel mechanismEstrogen receptorUterine plasma membranesInhibitory regulatorIschemic stroke injuryIschemic brain injury