Sylvie Dufour
Associate Research Scientist (Endocrinology)Cards
About
Research
Publications
2026
Distinct effects of ketogenic and non-ketogenic weight-loss diets on hepatic steatosis and mitochondrial metabolism in MASLD
Qadri S, Porthan K, Dufour S, Lehtimäki T, Petersen K, Shulman G, Yki-Järvinen H, Luukkonen P. Distinct effects of ketogenic and non-ketogenic weight-loss diets on hepatic steatosis and mitochondrial metabolism in MASLD. Journal Of Hepatology 2026 PMID: 41655910, DOI: 10.1016/j.jhep.2026.02.001.Peer-Reviewed Original ResearchNon-ketogenic dietIntrahepatic triglyceride contentKetogenic dietIntrahepatic triglycerideSteatosis resolutionLiver injuryPlasma concentrationsLiver diseaseSteatotic liver diseaseAbstractText Label="Background &Susceptible to liver injuryProton magnetic resonance spectroscopyLiver fat reductionProgressive liver injuryWeight lossOptimal dietary approachWeight-loss dietsConcentrations of branched-chain amino acidsBody fat lossBenefits of KDPlasma concentrations of branched-chain amino acidsSystemic metabolic responseBranched-chain amino acidsAbstractText Label="ImpactMitochondrial tricarboxylic acid
2025
Evolutionary adaptation of anaerobic and aerobic metabolism to high sulfide and hypoxic hydrothermal vent crab, Xenograpsus testudinatus
Chen C, Wu G, Tseng Y, Dufour S, Chang C. Evolutionary adaptation of anaerobic and aerobic metabolism to high sulfide and hypoxic hydrothermal vent crab, Xenograpsus testudinatus. Scientific Reports 2025, 16: 2123. PMID: 41392055, PMCID: PMC12808302, DOI: 10.1038/s41598-025-31968-1.Peer-Reviewed Original ResearchConceptsVent habitatsEnzymatic activityLong-term exposureVent crabsSulfide toleranceHydrothermal vent crabsHydrothermal vent habitatsAerobic metabolismIncrease of transcriptionHydrothermal vent environmentsAnaerobic metabolismHemolymph lactate levelsPhylogenetic analysisMitochondrial respiratory functionIntertidal speciesCapture siteEvolutionary adaptationSulfide detoxificationProducts of anaerobic metabolismAerobic respirationParalogsVent environmentsQuinone oxidoreductaseSulfide toxicityMetabolic adaptationCorrection: Microbial diversity and pigment synthesis in the accessory nidamental gland: species-specific and color-associated patterns in bigfin reef squid (Sepioteuthis lessoniana)
Chiu L, Guo J, Li H, Chang H, Yang S, Dufour S, Chang C, Tseng Y, Wu G. Correction: Microbial diversity and pigment synthesis in the accessory nidamental gland: species-specific and color-associated patterns in bigfin reef squid (Sepioteuthis lessoniana). Animal Microbiome 2025, 7: 109. PMID: 41107996, PMCID: PMC12535005, DOI: 10.1186/s42523-025-00481-1.Peer-Reviewed Original ResearchIn vitro and in silico insights on the regulation by gonadal hormones of pituitary GnRH receptor expression in a basal teleost, the European eel
Lin C, Rousseau K, Chang C, Dufour S. In vitro and in silico insights on the regulation by gonadal hormones of pituitary GnRH receptor expression in a basal teleost, the European eel. Frontiers In Endocrinology 2025, 16: 1673260. PMID: 41089285, PMCID: PMC12515627, DOI: 10.3389/fendo.2025.1673260.Peer-Reviewed Original ResearchConceptsTranscription Factor Binding SitesFactor binding sitesBasal teleostsGonadal hormonesLuteinizing hormoneRegulatory mechanismsDeficient productionPrimary culturesResponse to gonadotropin-releasing hormoneBinding sitesGnRH receptor expressionPituitary sensitivity to GnRHEffects of steroidsUnique life cycleNon-aromatizable androgensSexual maturityIn silico insightSensitivity to GnRHGonadotropin-releasing hormonePrimary cultures of eel pituitary cellsOvulatory luteinizing hormoneEvolutionary conservationEffects of testosteroneReceptor expressionEel pituitary cellsLes métamorphoses chez les poissons et leurs régulations endocriniennes
Dufour S, Sachs L, Martin P, Rousseau K. Les métamorphoses chez les poissons et leurs régulations endocriniennes. Biologie Aujourd Hui 2025, 219: 37-50. PMID: 40694674, DOI: 10.1051/jbio/2025002.Peer-Reviewed Original ResearchConceptsSecondary metamorphosisLarval metamorphosisEvolution of complex life cyclesEvolution of vertebratesControl of metabolismComplex life cycleControl of thyroid hormonesDiverse habitatsNeuroendocrine controlAnimal kingdomAmphibiansVertebrate metamorphosisMetamorphosis of amphibiansControl of metamorphosisGrowth phaseVertebratesJuvenile stageTeleostReproductive phaseMigratory fishHabitatMetamorphosisCyclostomesLarvalSalmon smoltificationRobustness of gametogenesis in the scleractinian coral, Tubastraea aurea, in the shallow-water hydrothermal vent field off Kueishan Island, northeastern Taiwan
Corrigan E, Chen C, Wang B, Dufour S, Chang C. Robustness of gametogenesis in the scleractinian coral, Tubastraea aurea, in the shallow-water hydrothermal vent field off Kueishan Island, northeastern Taiwan. The Science Of The Total Environment 2025, 992: 179901. PMID: 40561834, DOI: 10.1016/j.scitotenv.2025.179901.Peer-Reviewed Original ResearchConceptsScleractinian coralsReproductive resilienceHydrothermal ventsSexual reproductionT. aureaSeasonal timingCoral reef ecosystemsKueishan IslandSeasonal variationNortheastern TaiwanSexual reproductive strategiesEvolutionary time framesTiming of reproductionReef ecosystemsSeasonal timing of reproductionPresence of larvaeSea surface temperatureUnique ecosystemsOcean acidificationSeasonal variation of water temperatureHydrothermal vent fieldsVariation of water temperatureAcidified conditionsGametogenetic processesLarval production1647-P: Coenzyme A Synthase Knockdown Increases Hepatic Mitochondrial Fat Oxidation and Reduces Hepatic Steatosis and Hepatic Insulin Resistance
GASPAR R, SAKUMA I, HUBBARD B, LAMOIA T, ZHENG J, PARIKH S, KAHN M, SILVEIRA L, DUFOUR S, NASIRI A, PERELIS M, PETERSEN K, SAMUEL V, SHULMAN G. 1647-P: Coenzyme A Synthase Knockdown Increases Hepatic Mitochondrial Fat Oxidation and Reduces Hepatic Steatosis and Hepatic Insulin Resistance. Diabetes 2025, 74 DOI: 10.2337/db25-1647-p.Peer-Reviewed Original ResearchHFD-fed miceAcetyl-CoAHepatic insulin resistanceHFD-fedHepatic acetyl-CoA contentMalonyl-CoA levelsCoenzyme A synthaseFatty acid synthesisHepatic acetyl-CoAAcetyl-CoA contentSteatotic liver diseasePathogenesis of type 2 diabetesHigh-fat dietTCA cycleMitochondrial fat oxidationWhole-body energy expenditureCoA biosynthesisHepatic steatosisAcid synthesisMetabolic pathwaysInsulin resistanceReduced hepatic steatosisDecreased hepatic steatosisCOASYTriacylglycerol contentLiver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis
Sakuma I, Gaspar R, Nasiri A, Dufour S, Kahn M, Zheng J, LaMoia T, Guerra M, Taki Y, Kawashima Y, Yimlamai D, Perelis M, Vatner D, Petersen K, Huttasch M, Knebel B, Kahl S, Roden M, Samuel V, Tanaka T, Shulman G. Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2502978122. PMID: 40310463, PMCID: PMC12067271, DOI: 10.1073/pnas.2502978122.Peer-Reviewed Original ResearchConceptsCholine-deficient l-amino acid-defined high-fat dietBempedoic acidLiver fibrosisLiver diseaseL-amino acid-defined high-fat dietAdvanced liver diseaseCholesterol contentHSD17B13 variantsHigh-fat dietTotal liver cholesterol contentTreated miceActivate signaling pathwaysVariant rs738409Liver cholesterol contentLiver lipidsFibrotic responsePromote inflammationTherapeutic approachesSteatotic liver diseaseDietary cholesterol supplementationFibrosisHuman liver samplesI148MAntisense oligonucleotidesProgressive formCharacterization of a direct role of GnRHs in the control of spermiogenesis and steroidogenesis in the small-spotted catshark Scyliorhinus canicula
Jeanne F, Pilet S, Bernay B, Lagadu S, Delépée R, Dufour S, Sourdaine P. Characterization of a direct role of GnRHs in the control of spermiogenesis and steroidogenesis in the small-spotted catshark Scyliorhinus canicula. General And Comparative Endocrinology 2025, 368: 114734. PMID: 40254036, DOI: 10.1016/j.ygcen.2025.114734.Peer-Reviewed Original ResearchConceptsGrowth hormone receptorSmall-spotted catshark Scyliorhinus caniculaReal-time PCR analysisScyliorhinus caniculaCatshark Scyliorhinus caniculaSynteny analysisFemale reproductive tractSertoli cellsNanoLC-ESI-MS/MSSteroidogenic cellsTesticular explantsSpermiogenesisDNA structureS. caniculaHypothalamic gonadotropin-releasing hormonePCR analysisGonadotrope cellsIn situ hybridizationReproductive tractTestisProduction of gonadotropinsProteinGonadotropin-releasing hormoneHormone-receptor interactionVentral lobePleiotropic signaling of single-chain thyrostimulin (GPB5-GPA2) on homologous glycoprotein hormone receptors (ScFSHR, ScLHR, ScTSHR) in the elasmobranch Scyliorhinus canicula reproduction
Jeanne F, Pilet S, Combarnous Y, Bernay B, Dufour S, Favrel P, Sourdaine P. Pleiotropic signaling of single-chain thyrostimulin (GPB5-GPA2) on homologous glycoprotein hormone receptors (ScFSHR, ScLHR, ScTSHR) in the elasmobranch Scyliorhinus canicula reproduction. Molecular And Cellular Endocrinology 2025, 604: 112553. PMID: 40254178, DOI: 10.1016/j.mce.2025.112553.Peer-Reviewed Original ResearchConceptsLeucine-rich repeat G-protein coupled receptorSister groupFollicle-stimulating hormonePleiotropic signalingFemale tissuesGlycoprotein hormonesLuteinizing hormoneParacrine/autocrine functionsThyroid-stimulating hormone (TSHAncient cladeGlycoprotein hormone receptorsSmall-spotted catsharkGlycoprotein hormone subunitsSertoli cellsPhylogenetic interestBony vertebratesMale genital tractG protein-coupled receptorsGerm cellsGpa2Pituitary glycoprotein hormonesExpression of TSHRReal-time PCRIn situ hybridizationB subunit