2002
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
Jordt SE, Julius D. Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers. Cell 2002, 108: 421-430. PMID: 11853675, DOI: 10.1016/s0092-8674(02)00637-2.Peer-Reviewed Original ResearchConceptsMolecular basisSpecies-specific behavioural responsesSpecies-specific sensitivitySeed dispersalMammalian counterpartsChili pepperChicken receptorPredatory mammalsRat vanilloid receptorEcological phenomenaMammalsPain-producing effectsBirdsVanilloid receptorsRecent acquisitionPepperCompound capsaicinReceptorsDispersalBehavioral responsesDomainChickensBasis
2001
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
Chuang H, Prescott E, Kong H, Shields S, Jordt S, Basbaum A, Chao M, Julius D. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 2001, 411: 957-962. PMID: 11418861, DOI: 10.1038/35082088.Peer-Reviewed Original ResearchConceptsPlasma membrane phosphatidylinositolNerve growth factorTyrosine kinase receptorsActivation of PLCGrowth factorTRP channel familyMembrane phosphatidylinositolChannel familyKinase receptorsBiochemical mechanismsMolecular levelBiochemical studiesIon channelsCellular levelChannel activityHeat-activated ion channelExpression of VR1Sensory nerve endingsChemical stimuliSense of painSensory neuronsEndogenous factorsPrimary afferentsNerve endingsCapsaicin receptor
2000
Acid potentiation of the capsaicin receptor determined by a key extracellular site
Jordt S, Tominaga M, Julius D. Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 8134-8139. PMID: 10859346, PMCID: PMC16682, DOI: 10.1073/pnas.100129497.Peer-Reviewed Original Research