2017
Ankyrin‐rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1‐function in nociceptive neurons
Peter J, Kasper C, Kaufholz M, Buschow R, Isensee J, Hucho T, Herberg F, Schwede F, Stein C, Jordt S, Brackmann M, Spahn V. Ankyrin‐rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1‐function in nociceptive neurons. European Journal Of Pain 2017, 21: 1072-1086. PMID: 28182310, PMCID: PMC5504413, DOI: 10.1002/ejp.1008.Peer-Reviewed Original ResearchConceptsAnkyrin-rich membranePKA-dependent mannerKinase DHEK-293 cellsSensitivity of TRPV1Immunoprecipitation experimentsDRG neuronsNovel modulatorRodent DRG neuronsIon channelsIon channel TRPV1Excitatory ion channelSmall-diameter dorsal root ganglion neuronsTransient receptor potential vanilloidImportant componentDorsal root ganglion neuronsPeripheral sensory neuronsMouse DRG neuronsChemical stimuliSensory neuronsCellsComplexesMembraneDirect modificationTRPV1 expression
2001
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
Chuang H, Prescott E, Kong H, Shields S, Jordt S, Basbaum A, Chao M, Julius D. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 2001, 411: 957-962. PMID: 11418861, DOI: 10.1038/35082088.Peer-Reviewed Original ResearchConceptsPlasma membrane phosphatidylinositolNerve growth factorTyrosine kinase receptorsActivation of PLCGrowth factorTRP channel familyMembrane phosphatidylinositolChannel familyKinase receptorsBiochemical mechanismsMolecular levelBiochemical studiesIon channelsCellular levelChannel activityHeat-activated ion channelExpression of VR1Sensory nerve endingsChemical stimuliSense of painSensory neuronsEndogenous factorsPrimary afferentsNerve endingsCapsaicin receptor