1993
Correction of Hyperinsulinemia by Glyburide Treatment in Nondiabetic Patients with Thalassemia Major
Jones T, Boulware S, Caprio S, Merkel P, Amiel S, Pearson H, Sherwin R, Tamborlane W. Correction of Hyperinsulinemia by Glyburide Treatment in Nondiabetic Patients with Thalassemia Major. Pediatric Research 1993, 33: 497-500. PMID: 8511023, DOI: 10.1203/00006450-199305000-00015.Peer-Reviewed Original ResearchConceptsDevelopment of diabetesGlyburide therapyInsulin responseNondiabetic patientsOral glucoseThalassemia majorInsulin-stimulated glucose metabolismCorrection of hyperinsulinemiaOral hypoglycemic agentsPlasma insulin responseEarly metabolic defectsEuglycemic insulin clampLow-dose treatmentPlasma glucose responseSecond-generation oral hypoglycemic agentsGlyburide treatmentInsulin hypersecretionInsulin clampInsulin resistanceHypoglycemic agentsThalassemic patientsM2/minGlucose metabolismPatientsGlucose response
1992
Effect of growth hormone treatment on hyperinsulinemia associated with turner syndrome
Caprio S, Boulware S, Press M, Sherwin R, Rubin K, Carpenter T, Plewe G, Tamborlane W. Effect of growth hormone treatment on hyperinsulinemia associated with turner syndrome. The Journal Of Pediatrics 1992, 120: 238-243. PMID: 1735819, DOI: 10.1016/s0022-3476(05)80434-2.Peer-Reviewed Original ResearchConceptsControl subjectsGrowth hormoneTurner syndromeHyperinsulinemic responseInsulin responseHyperglycemic glucose clamp techniqueSecond-phase insulin responseInsulin-stimulated glucose metabolismGlucose-stimulated insulin responseMonths of therapyMonths of treatmentTotal cholesterol levelsExcessive insulin secretionGrowth hormone treatmentGlucose clamp techniqueGlucose clamp procedureHuman growth hormoneBlood pressureGlucose incrementGlycosylated hemoglobinInsulin resistancePlasma levelsCholesterol levelsClamp procedureHealthy children