2022
The fates of internalized NaV1.7 channels in sensory neurons: Retrograde cotransport with other ion channels, axon-specific recycling, and degradation
Higerd-Rusli G, Tyagi S, Liu S, Dib-Hajj F, Waxman S, Dib-Hajj S. The fates of internalized NaV1.7 channels in sensory neurons: Retrograde cotransport with other ion channels, axon-specific recycling, and degradation. Journal Of Biological Chemistry 2022, 299: 102816. PMID: 36539035, PMCID: PMC9843449, DOI: 10.1016/j.jbc.2022.102816.Peer-Reviewed Original ResearchConceptsMembrane proteinsIon channelsNeuronal functionDistinct neuronal compartmentsAxonal membrane proteinsRetrograde traffickingNeuronal polarityRecycling pathwayLate endosomesPlasma membraneSpecific proteinsAxonal traffickingNovel mechanismCell membraneSodium channel NaNeuronal compartmentsMultiple pathwaysLive neuronsVoltage-gated sodium channel NaProteinEndocytosisMembrane specializationsTraffickingMembraneChannel Na
2020
Cumulative hydropathic topology of a voltage‐gated sodium channel at atomic resolution
Xenakis M, Kapetis D, Yang Y, Heijman J, Waxman S, Lauria G, Faber C, Smeets H, Westra R, Lindsey P. Cumulative hydropathic topology of a voltage‐gated sodium channel at atomic resolution. Proteins Structure Function And Bioinformatics 2020, 88: 1319-1328. PMID: 32447794, DOI: 10.1002/prot.25951.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceArcobacterBacterial ProteinsBinding SitesHydrophobic and Hydrophilic InteractionsIon Channel GatingModels, MolecularProtein BindingProtein Conformation, alpha-HelicalProtein Conformation, beta-StrandProtein Interaction Domains and MotifsSodiumThermodynamicsVoltage-Gated Sodium ChannelsConceptsVoltage-gated sodium channelsBacterial channelsPhysiological cellular activitySodium channelsCellular activitiesCell membraneBiological poresPore stabilityAtomic resolutionBiophysical significanceMembrane surfaceHydropathicityGenesProteinMutationsWide spectrumMembraneFunctional architectureAccumulationComputational frameworkSodium ionsPores
1995
Voltage-gated ion channels in axons: Localization, function, and development
WAXMAN S. Voltage-gated ion channels in axons: Localization, function, and development. 1995, 218-243. DOI: 10.1093/acprof:oso/9780195082937.003.0011.Peer-Reviewed Original ResearchThe oligodendrocyte, the perinodal astrocyte, and the central node of Ranvier
BLACK J, SONTHEIMER H, OH Y, WAXMAN S. The oligodendrocyte, the perinodal astrocyte, and the central node of Ranvier. 1995, 116-143. DOI: 10.1093/acprof:oso/9780195082937.003.0006.Peer-Reviewed Original Research
1987
Molecular Organization of the Cell Membrane in Normal and Pathological Axons: Relation to Glial Contact
Waxman S. Molecular Organization of the Cell Membrane in Normal and Pathological Axons: Relation to Glial Contact. NATO ASI Series 1987, 709-736. DOI: 10.1007/978-3-642-71381-1_43.Peer-Reviewed Original ResearchCell membraneMolecular organizationMolecular differentiationCell recognition moleculesVoltage-sensitive sodium channelsVoltage-sensitive potassium channelsIon channel organizationIon channel populationsCell typesAdult mammalsRecognition moleculesCoordinated mannerMyelin-forming cellsPotassium channelsChannel populationsGlial cellsMembraneSodium channelsDifferentiationCellsRecent studiesAxon membraneChannel organizationGlial contactMammals
1985
Organization of Ion Channels in the Myelinated Nerve Fiber
Waxman S, Ritchie J. Organization of Ion Channels in the Myelinated Nerve Fiber. Science 1985, 228: 1502-1507. PMID: 2409596, DOI: 10.1126/science.2409596.Peer-Reviewed Original Research
1980
Coordinated micropinocytotic activity of adjacent neuronal membranes in mammalian central nervous system
Waxman S, Waxman M, Pappas G. Coordinated micropinocytotic activity of adjacent neuronal membranes in mammalian central nervous system. Neuroscience Letters 1980, 20: 141-146. PMID: 7443064, DOI: 10.1016/0304-3940(80)90136-6.Peer-Reviewed Original ResearchConceptsExocytosis/endocytosisMembrane infoldingsMammalian central nervous systemCoated invaginationsNon-synaptic sitesNeuronal membranesCell membraneCentral nervous systemCoordinated activityNervous systemMembraneInvaginationMicropinocytotic activityInfoldingsElectrotonic synapsesEndocytosisSpeciesCytoplasmTissueNumber of sitesSitesSynapsesWide varietyActivityNeighboring dendrites