2015
Low circulating levels of bisphenol‐A induce cognitive deficits and loss of asymmetric spine synapses in dorsolateral prefrontal cortex and hippocampus of adult male monkeys
Elsworth JD, Jentsch JD, Groman SM, Roth RH, Redmond ED, Leranth C. Low circulating levels of bisphenol‐A induce cognitive deficits and loss of asymmetric spine synapses in dorsolateral prefrontal cortex and hippocampus of adult male monkeys. The Journal Of Comparative Neurology 2015, 523: 1248-1257. PMID: 25557059, PMCID: PMC4390445, DOI: 10.1002/cne.23735.Peer-Reviewed Original ResearchConceptsLevels of BPARegimen of exposureAdult male vervet monkeysExcitatory synaptic inputsAsymmetric spine synapsesAdult male monkeysImpact of BPADorsolateral prefrontal cortexPyramidal neuronsSpine synapsesSynaptic effectsCognitive dysfunctionMale vervet monkeysSynaptic inputsDendritic spinesPrimate brainExposure of humansMale monkeysBrain regionsCognitive deficitsLevels of bisphenolPrefrontal cortexAdverse effectsManufacture of plasticsStudies of humans
2007
Dimensions of Impulsivity Are Associated with Poor Spatial Working Memory Performance in Monkeys
James AS, Groman SM, Seu E, Jorgensen M, Fairbanks LA, Jentsch JD. Dimensions of Impulsivity Are Associated with Poor Spatial Working Memory Performance in Monkeys. Journal Of Neuroscience 2007, 27: 14358-14364. PMID: 18160643, PMCID: PMC6673444, DOI: 10.1523/jneurosci.4508-07.2007.Peer-Reviewed Original ResearchConceptsDimensions of impulsivityMemory performanceNonsocial stimuliResponse taskImpulsive behaviorDRD4 genotypeAttention-deficit/hyperactivity disorderDeficit/hyperactivity disorderSpatial Working Memory PerformanceHigh impulsive animalsWorking Memory PerformanceDelayed response taskDimensions of temperamentLow impulsive subjectsDRD4 allelesNeurocognitive endophenotypesDopamine D4 receptor geneHyperactivity disorderD4 receptor geneDimensional phenotypesCorrect responsesDelay versionImpulsivityCeiling levelImpulsive approachDopamine D2/D3 Receptors Play a Specific Role in the Reversal of a Learned Visual Discrimination in Monkeys
Lee B, Groman S, London ED, Jentsch JD. Dopamine D2/D3 Receptors Play a Specific Role in the Reversal of a Learned Visual Discrimination in Monkeys. Neuropsychopharmacology 2007, 32: 2125-2134. PMID: 17299511, DOI: 10.1038/sj.npp.1301337.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBenzazepinesBrainChlorocebus aethiopsDiscrimination LearningDopamineDopamine AntagonistsDopamine D2 Receptor AntagonistsDose-Response Relationship, DrugMaleNeuropsychological TestsPattern Recognition, VisualPhotic StimulationRacloprideReceptors, Dopamine D1Receptors, Dopamine D2Receptors, Dopamine D3ConceptsD2/D3 receptorsReversal learningReversal sessionsVisual discriminationRetention sessionNovel discriminationD3 receptorsD1/D5 receptor antagonist SCH 23390Receptor antagonist SCH 23390Dopamine D2/D3 receptorsWisconsin General Test ApparatusD2/D3 receptor antagonist racloprideStimulus-reward contingenciesStimulus-reward associationsAntagonist SCH 23390Receptor antagonist racloprideVisual discrimination taskD2-like receptorsDopamine receptor antagonistUnique visual cuesMesocorticolimbic dopaminergic systemPhasic DA releaseNon-human primatesDopaminergic mechanismsAntagonist raclopride