2015
Low circulating levels of bisphenol‐A induce cognitive deficits and loss of asymmetric spine synapses in dorsolateral prefrontal cortex and hippocampus of adult male monkeys
Elsworth JD, Jentsch JD, Groman SM, Roth RH, Redmond ED, Leranth C. Low circulating levels of bisphenol‐A induce cognitive deficits and loss of asymmetric spine synapses in dorsolateral prefrontal cortex and hippocampus of adult male monkeys. The Journal Of Comparative Neurology 2015, 523: 1248-1257. PMID: 25557059, PMCID: PMC4390445, DOI: 10.1002/cne.23735.Peer-Reviewed Original ResearchConceptsLevels of BPARegimen of exposureAdult male vervet monkeysExcitatory synaptic inputsAsymmetric spine synapsesAdult male monkeysImpact of BPADorsolateral prefrontal cortexPyramidal neuronsSpine synapsesSynaptic effectsCognitive dysfunctionMale vervet monkeysSynaptic inputsDendritic spinesPrimate brainExposure of humansMale monkeysBrain regionsCognitive deficitsLevels of bisphenolPrefrontal cortexAdverse effectsManufacture of plasticsStudies of humans
2014
Primate Phencyclidine Model of Schizophrenia: Sex-Specific Effects on Cognition, Brain Derived Neurotrophic Factor, Spine Synapses, and Dopamine Turnover in Prefrontal Cortex
Elsworth JD, Groman SM, Jentsch JD, Leranth C, Redmond DE, Kim JD, Diano S, Roth RH. Primate Phencyclidine Model of Schizophrenia: Sex-Specific Effects on Cognition, Brain Derived Neurotrophic Factor, Spine Synapses, and Dopamine Turnover in Prefrontal Cortex. The International Journal Of Neuropsychopharmacology 2014, 18: pyu048. PMID: 25522392, PMCID: PMC4438537, DOI: 10.1093/ijnp/pyu048.Peer-Reviewed Original ResearchConceptsSpine synapse numberDorsolateral prefrontal cortexDopamine turnoverPhencyclidine treatmentSpine synapsesSynapse numberCognitive deficitsPrefrontal cortexPhencyclidine modelMale monkeysJuvenile monkeysSchizophrenia-related cognitive deficitsDendritic spine synapsesIncidence of schizophreniaAdult male monkeysSex-specific effectsMessenger RNABDNF expressionNeurotrophic factorNovel treatmentsCombined groupAdult nonhumanCore symptomsCortexNonhuman primatesIn the Blink of an Eye: Relating Positive-Feedback Sensitivity to Striatal Dopamine D2-Like Receptors through Blink Rate
Groman SM, James AS, Seu E, Tran S, Clark TA, Harpster SN, Crawford M, Burtner JL, Feiler K, Roth RH, Elsworth JD, London ED, Jentsch JD. In the Blink of an Eye: Relating Positive-Feedback Sensitivity to Striatal Dopamine D2-Like Receptors through Blink Rate. Journal Of Neuroscience 2014, 34: 14443-14454. PMID: 25339755, PMCID: PMC4205561, DOI: 10.1523/jneurosci.3037-14.2014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlinkingChlorocebus aethiopsCorpus StriatumDiscrimination LearningFeedback, PhysiologicalMalePhotic StimulationReceptors, Dopamine D2Time FactorsConceptsDopamine D2-like receptorsD2-like receptorsPositron emission tomographyStriatal dopamine D2-like receptorsPositive feedback sensitivityAdult male vervet monkeysDopamine D2 receptorsD2-like receptor availabilityDopaminergic transmissionPharmacological assessmentD2 receptorsMale vervet monkeysReceptor numberReceptor availabilityEmission tomographyBlink rateReceptorsSimple behavioral measurePET measurementsHuman brainReversal-learning performanceVervet monkeysBehavioral measuresHuman impulsivityBehavioral addictions
2013
Methamphetamine-induced increases in putamen gray matter associate with inhibitory control
Groman SM, Morales AM, Lee B, London ED, Jentsch JD. Methamphetamine-induced increases in putamen gray matter associate with inhibitory control. Psychopharmacology 2013, 229: 527-538. PMID: 23748383, PMCID: PMC3770792, DOI: 10.1007/s00213-013-3159-9.Peer-Reviewed Original ResearchMeSH KeywordsAmphetamine-Related DisordersAnimalsChlorocebus aethiopsCognitionDiscrimination, PsychologicalDose-Response Relationship, DrugInhibition, PsychologicalMagnetic Resonance ImagingMaleMethamphetaminePositron-Emission TomographyPutamenReceptors, Dopamine D2Retention, PsychologyReversal LearningTime FactorsConceptsD2-like receptorsGray matterDrug usePositron emission tomography scanDopamine D2-like receptorsDrug-experienced individualsHuman methamphetamine usersRegimen of methamphetamineEmission tomography scanGray matter abnormalitiesMethamphetamine-induced increasesDrug-induced changesInhibitory controlNeurobiological risk factorsDopaminergic markersRisk factorsTomography scanDAT availabilityRight putamenTransporter availabilityPharmacological effectsStructural abnormalitiesRegimenMagnetic resonance imagesObjectivesThe purposeMonoamine Levels Within the Orbitofrontal Cortex and Putamen Interact to Predict Reversal Learning Performance
Groman SM, James AS, Seu E, Crawford MA, Harpster SN, Jentsch JD. Monoamine Levels Within the Orbitofrontal Cortex and Putamen Interact to Predict Reversal Learning Performance. Biological Psychiatry 2013, 73: 756-762. PMID: 23332512, PMCID: PMC3615106, DOI: 10.1016/j.biopsych.2012.12.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaudate NucleusChlorocebus aethiopsDiscrimination LearningDopamineFrontal LobeMalePutamenReversal LearningSerotoninConceptsGoal-directed behaviorOrbitofrontal cortexReward-directed behaviorPsychiatric disordersObsessive-compulsive disorderIndividual differencesAssociative learningInflexible behaviorBehavioral flexibilityBehavioral addictionsCompulsive behaviorsImportant modulatory influenceDiscrimination problemNeuromodulatory systemsPutamen dopamineNeurochemical dysfunctionBehavioral impairmentsNeurochemical levelsNeurochemical systemsDorsal striatumModulatory influenceCurrent studyDopamine levelsCortexNeurochemical differences
2012
Dysregulation of D2-Mediated Dopamine Transmission in Monkeys after Chronic Escalating Methamphetamine Exposure
Groman SM, Lee B, Seu E, James AS, Feiler K, Mandelkern MA, London ED, Jentsch JD. Dysregulation of D2-Mediated Dopamine Transmission in Monkeys after Chronic Escalating Methamphetamine Exposure. Journal Of Neuroscience 2012, 32: 5843-5852. PMID: 22539846, PMCID: PMC3353813, DOI: 10.1523/jneurosci.0029-12.2012.Peer-Reviewed Original ResearchMeSH Keywords3,4-Dihydroxyphenylacetic AcidAnalysis of VarianceAnimalsBehavior, AnimalBrainCentral Nervous System StimulantsChlorocebus aethiopsChoice BehaviorDiscrimination LearningDopamineDopamine Plasma Membrane Transport ProteinsDose-Response Relationship, DrugDrug Administration ScheduleFeedback, SensoryHomovanillic AcidMagnetic Resonance ImagingMaleMethamphetaminePositron-Emission TomographyReceptors, Dopamine D2Retention, PsychologyReversal LearningSynaptic TransmissionTime FactorsConceptsInhibitory control deficitsIndividual differencesInhibitory controlStimulus-outcome associationsLike receptor availabilityReversal-learning performancePositive feedback sensitivityStimulant-dependent individualsSubstance abuse behaviorsDopamine transmissionDrug-induced neuroadaptationsControl deficitsSelective impairmentDrugs of abuseDopaminergic neurochemistryEscalating-dose regimenLike receptorsMethamphetamine exposureSubstance dependenceDopamine systemBrain dopamine levelsDopamine transporter availabilityDopaminergic neurotransmissionReceptor availabilityDeficits
2011
Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration
Elsworth JD, Groman SM, Jentsch JD, Valles R, Shahid M, Wong E, Marston H, Roth RH. Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration. Neuropharmacology 2011, 62: 1442-1452. PMID: 21875607, PMCID: PMC3711239, DOI: 10.1016/j.neuropharm.2011.08.026.Peer-Reviewed Original ResearchConceptsBrain regionsExecutive functionCognitive dysfunctionPrefrontal cortexCognitive deficitsSubchronic phencyclidine administrationCognition-enhancing effectsDysregulation of neurotransmissionSame brain regionsReversal taskSpecific brain regionsPoor reversalAsenapine effectsOrbitofrontal cortexTrend levelSerotonin turnoverSerotonin utilizationControl monkeysFine motor functionPhencyclidine administrationMotor functionDeficitsDaily administrationNormal monkeysDiscrete brain regionsDorsal Striatal D2-Like Receptor Availability Covaries with Sensitivity to Positive Reinforcement during Discrimination Learning
Groman SM, Lee B, London ED, Mandelkern MA, James AS, Feiler K, Rivera R, Dahlbom M, Sossi V, Vandervoort E, Jentsch JD. Dorsal Striatal D2-Like Receptor Availability Covaries with Sensitivity to Positive Reinforcement during Discrimination Learning. Journal Of Neuroscience 2011, 31: 7291-7299. PMID: 21593313, PMCID: PMC3114883, DOI: 10.1523/jneurosci.0363-11.2011.Peer-Reviewed Original ResearchConceptsLike receptor availabilityIndividual differencesDiscrimination learningBehavioral flexibilitySpecific neurocognitive mechanismsVisual discrimination problemsBehavioral sensitivityReceptor availabilityNeurocognitive mechanismsReward sensitivityBehavioral performanceNeural mechanismsVisual discriminationNeuropsychiatric disordersPositive reinforcementReversal phaseEnvironmental contingenciesThree-choiceNumber of trialsPhenotypic dimensionsPsychiatric conditionsFeedback sensitivityLearningElectrophysiological findingsDisorders
2007
Dimensions of Impulsivity Are Associated with Poor Spatial Working Memory Performance in Monkeys
James AS, Groman SM, Seu E, Jorgensen M, Fairbanks LA, Jentsch JD. Dimensions of Impulsivity Are Associated with Poor Spatial Working Memory Performance in Monkeys. Journal Of Neuroscience 2007, 27: 14358-14364. PMID: 18160643, PMCID: PMC6673444, DOI: 10.1523/jneurosci.4508-07.2007.Peer-Reviewed Original ResearchConceptsDimensions of impulsivityMemory performanceNonsocial stimuliResponse taskImpulsive behaviorDRD4 genotypeAttention-deficit/hyperactivity disorderDeficit/hyperactivity disorderSpatial Working Memory PerformanceHigh impulsive animalsWorking Memory PerformanceDelayed response taskDimensions of temperamentLow impulsive subjectsDRD4 allelesNeurocognitive endophenotypesDopamine D4 receptor geneHyperactivity disorderD4 receptor geneDimensional phenotypesCorrect responsesDelay versionImpulsivityCeiling levelImpulsive approachDopamine D2/D3 Receptors Play a Specific Role in the Reversal of a Learned Visual Discrimination in Monkeys
Lee B, Groman S, London ED, Jentsch JD. Dopamine D2/D3 Receptors Play a Specific Role in the Reversal of a Learned Visual Discrimination in Monkeys. Neuropsychopharmacology 2007, 32: 2125-2134. PMID: 17299511, DOI: 10.1038/sj.npp.1301337.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBenzazepinesBrainChlorocebus aethiopsDiscrimination LearningDopamineDopamine AntagonistsDopamine D2 Receptor AntagonistsDose-Response Relationship, DrugMaleNeuropsychological TestsPattern Recognition, VisualPhotic StimulationRacloprideReceptors, Dopamine D1Receptors, Dopamine D2Receptors, Dopamine D3ConceptsD2/D3 receptorsReversal learningReversal sessionsVisual discriminationRetention sessionNovel discriminationD3 receptorsD1/D5 receptor antagonist SCH 23390Receptor antagonist SCH 23390Dopamine D2/D3 receptorsWisconsin General Test ApparatusD2/D3 receptor antagonist racloprideStimulus-reward contingenciesStimulus-reward associationsAntagonist SCH 23390Receptor antagonist racloprideVisual discrimination taskD2-like receptorsDopamine receptor antagonistUnique visual cuesMesocorticolimbic dopaminergic systemPhasic DA releaseNon-human primatesDopaminergic mechanismsAntagonist raclopride