2013
Monoamine Levels Within the Orbitofrontal Cortex and Putamen Interact to Predict Reversal Learning Performance
Groman SM, James AS, Seu E, Crawford MA, Harpster SN, Jentsch JD. Monoamine Levels Within the Orbitofrontal Cortex and Putamen Interact to Predict Reversal Learning Performance. Biological Psychiatry 2013, 73: 756-762. PMID: 23332512, PMCID: PMC3615106, DOI: 10.1016/j.biopsych.2012.12.002.Peer-Reviewed Original ResearchConceptsGoal-directed behaviorOrbitofrontal cortexReward-directed behaviorPsychiatric disordersObsessive-compulsive disorderIndividual differencesAssociative learningInflexible behaviorBehavioral flexibilityBehavioral addictionsCompulsive behaviorsImportant modulatory influenceDiscrimination problemNeuromodulatory systemsPutamen dopamineNeurochemical dysfunctionBehavioral impairmentsNeurochemical levelsNeurochemical systemsDorsal striatumModulatory influenceCurrent studyDopamine levelsCortexNeurochemical differences
2011
Cognitive control and the dopamine D2‐like receptor: a dimensional understanding of addiction
Groman SM, Jentsch JD. Cognitive control and the dopamine D2‐like receptor: a dimensional understanding of addiction. Depression And Anxiety 2011, 29: 295-306. PMID: 22147558, DOI: 10.1002/da.20897.Peer-Reviewed Original ResearchConceptsCognitive controlCognitive control abilitiesSubstantial psychosocial impairmentCognitive processesPsychosocial impairmentDimensional understandingCognitive dysfunctionControl abilityCategorical diagnosesPsychiatric conditionsParticular dimensionAddictionPsychiatric disordersImpairmentDisordersDA receptor functionPoint of convergenceCrucial dimensionDimensional natureReceptor transmissionDopamine D2-like receptorsFeelingsSymptomatologyTreatment responseD2-like receptors