Cyst growth, polycystins, and primary cilia in autosomal dominant polycystic kidney disease
Lee SH, Somlo S. Cyst growth, polycystins, and primary cilia in autosomal dominant polycystic kidney disease. Kidney Research And Clinical Practice 2014, 33: 73-78. PMID: 26877954, PMCID: PMC4714135, DOI: 10.1016/j.krcp.2014.05.002.Peer-Reviewed Original ResearchPrimary ciliaAutosomal dominant polycystic kidney diseaseCarboxy-terminal tailDominant polycystic kidney diseaseExtracellular stimuliPolycystic kidney diseasePolycystin functionChannel proteinsPolycystinsPKD1 geneCystic kidney diseaseCiliaCalcium signalsRenal epitheliumProteinIntact ciliaKidney diseaseGenesCyst growthCurrent understandingReduced levelsPathwayComplete inactivationInactivationRecent dataPolycystin-1: a master regulator of intersecting cystic pathways
Fedeles SV, Gallagher AR, Somlo S. Polycystin-1: a master regulator of intersecting cystic pathways. Trends In Molecular Medicine 2014, 20: 251-260. PMID: 24491980, PMCID: PMC4008641, DOI: 10.1016/j.molmed.2014.01.004.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseaseAutosomal recessive polycystic kidney diseaseAutosomal dominant polycystic liver diseasePolycystic kidney diseaseKidney diseasePolycystic liver diseaseRecessive polycystic kidney diseaseDominant polycystic kidney diseaseLiver diseasePolycystic diseaseCyst growthLethal monogenic disorderCyst formationTranslational implicationsDiseaseMonogenic disordersCausative genesCystic phenotypeRecent dataPolycystin-1Polycystin-2Master regulator