2016
Characterization of Diabetogenic CD8+ T Cells IMMUNE THERAPY WITH METABOLIC BLOCKADE*
Garyu JW, Uduman M, Stewart A, Rui J, Deng S, Shenson J, Staron MM, Kaech SM, Kleinstein SH, Herold KC. Characterization of Diabetogenic CD8+ T Cells IMMUNE THERAPY WITH METABOLIC BLOCKADE*. Journal Of Biological Chemistry 2016, 291: 11230-11240. PMID: 26994137, PMCID: PMC4900270, DOI: 10.1074/jbc.m115.713362.Peer-Reviewed Original ResearchConceptsPrediabetic NOD miceNOD miceT cellsDiabetogenic CD8Reactive cellsMemory precursor effector cellsType 1 diabetes mellitusΒ-cellsGlucose tolerance deterioratesAutoreactive T cellsHyperglycemic NOD miceInsulin-producing β-cellsAutoimmune effectorsAutoimmune diabetesReactive CD8Glucose intoleranceDiabetes mellitusEffector cellsImmune therapyMetabolic disturbancesTolerance deterioratesDisease progressionInsulin pelletsSubset of cellsConventional antigens
2014
CD45 ligation expands Tregs by promoting interactions with DCs
Camirand G, Wang Y, Lu Y, Wan YY, Lin Y, Deng S, Guz G, Perkins DL, Finn PW, Farber DL, Flavell RA, Shlomchik WD, Lakkis FG, Rudd CE, Rothstein DM. CD45 ligation expands Tregs by promoting interactions with DCs. Journal Of Clinical Investigation 2014, 124: 4603-4613. PMID: 25202978, PMCID: PMC4191025, DOI: 10.1172/jci74087.Peer-Reviewed Original ResearchConceptsT cellsTreg proliferationTreg expansionVivo expansionRegulatory T cellsConventional T cellsTransfer of TregsActivated T cellsTreg numbersTreg populationImmune toleranceHomeostatic proliferationWT miceExogenous antigensPeripheral homeostasisTregsImmune responseTherapeutic useCD45 ligationNuclear factorIntegrin-dependent mannerNuclear translocationLigationAntigenProliferation
2005
Testicular Immune Privilege Promotes Transplantation Tolerance by Altering the Balance between Memory and Regulatory T Cells
Nasr IW, Wang Y, Gao G, Deng S, Diggs L, Rothstein DM, Tellides G, Lakkis FG, Dai Z. Testicular Immune Privilege Promotes Transplantation Tolerance by Altering the Balance between Memory and Regulatory T Cells. The Journal Of Immunology 2005, 174: 6161-6168. PMID: 15879112, DOI: 10.4049/jimmunol.174.10.6161.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BlockingApoptosisCD40 AntigensCD40 LigandCD8-Positive T-LymphocytesEpitopes, T-LymphocyteGraft RejectionGrowth InhibitorsImmunologic MemoryIslets of Langerhans TransplantationLymphocyte ActivationLymphocyte CountMaleMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLMice, KnockoutMice, TransgenicReceptors, Interleukin-2TestisT-Lymphocytes, RegulatoryTransplantation ToleranceTransplantation, HeterotopicConceptsRegulatory T cellsNon-privileged sitesIslet allograftsTransplantation toleranceT cellsImmune privilegeCD40/CD40L costimulationIntratesticular islet allograftsIslet allograft toleranceAcute allograft rejectionProlong allograft survivalLate allograft failureTesticular immune privilegePrivileged siteAllograft failureAllograft survivalAllograft toleranceCostimulatory blockadeAllograft rejectionAlloimmune responseSkin allograftsIslet transplantationImmune regulationImmune responseAllograftsImpaired Recall of CD8 Memory T Cells in Immunologically Privileged Tissue
Dai Z, Nasr IW, Reel M, Deng S, Diggs L, Larsen CP, Rothstein DM, Lakkis FG. Impaired Recall of CD8 Memory T Cells in Immunologically Privileged Tissue. The Journal Of Immunology 2005, 174: 1165-1170. PMID: 15661869, DOI: 10.4049/jimmunol.174.3.1165.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCD8-Positive T-LymphocytesCell MovementEpitopes, T-LymphocyteFas ReceptorGraft RejectionImmunologic MemoryIslets of Langerhans TransplantationKi-1 AntigenKidneyMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred MRL lprMice, KnockoutMice, Mutant StrainsMice, TransgenicTestisTransplantation, HeterotopicConceptsMemory T cellsCD8 memory T cellsT cellsForeign AgsPrivileged tissuesT cell-mediated rejectionCell-mediated rejectionPancreatic islet allograftsDelayed graft rejectionTNFR family membersPrivileged siteIntratesticular graftsGraft rejectionIslet allograftsImmunosuppressive mechanismsImmune privilegeAllogeneic graftsDiabetic miceKidney capsuleSame AgTumor cellsGraftImpaired recallFamily membersCells