2012
Analysis of Human Biologics With a Mouse Skin Transplant Model in Humanized Mice
Waldron-Lynch F, Deng S, Preston-Hurlburt P, Henegariu O, Herold KC. Analysis of Human Biologics With a Mouse Skin Transplant Model in Humanized Mice. American Journal Of Transplantation 2012, 12: 2652-2662. PMID: 22900715, DOI: 10.1111/j.1600-6143.2012.04178.x.Peer-Reviewed Original ResearchConceptsSkin transplant modelGraft rejectionTransplant modelHumanized miceSkin graftsT cellsFunctional human immune responsesMouse skin transplant modelMurine skin transplant modelCentral memory T cellsNOD/SCID/Mouse skin graftsMemory T cellsMonoclonal antibody therapySkin graft rejectionDevelopment of effectorHuman immune responseMHC class IHuman T cellsIpilimumab treatmentAntibody therapySCID/Diffuse infiltrationMouse donorsSerum immunoglobulins
2001
Targeting Signal 1 Through CD45RB Synergizes with CD40 Ligand Blockade and Promotes Long Term Engraftment and Tolerance in Stringent Transplant Models
Rothstein D, Livak M, Kishimoto K, Ariyan C, Qian H, Fecteau S, Sho M, Deng S, Zheng X, Sayegh M, Basadonna G. Targeting Signal 1 Through CD45RB Synergizes with CD40 Ligand Blockade and Promotes Long Term Engraftment and Tolerance in Stringent Transplant Models. The Journal Of Immunology 2001, 166: 322-329. PMID: 11123308, DOI: 10.4049/jimmunol.166.1.322.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAnimalsAntibodies, BlockingAntibodies, MonoclonalB-LymphocytesCD40 LigandCD8-Positive T-LymphocytesCell MovementCytokinesDrug Therapy, CombinationGraft SurvivalIslets of Langerhans TransplantationLeukocyte Common AntigensMaleMiceMice, Inbred BALB CMice, Inbred C57BLModels, ImmunologicalMonocytesProtein IsoformsSignal TransductionSkin TransplantationTransplantation ToleranceConceptsCostimulatory blockadeCD40 ligand blockadeStringent transplant modelSkin allograft survivalBlockade of CD28Induction of toleranceTh2 cytokine expressionLong-term engraftmentImmunogenic allograftAllograft survivalAllograft toleranceAllograft rejectionC57BL/6 recipientsCD8 cellsIslet allograftsTh1 cytokinesTransplant modelCostimulatory pathwayCytokine expressionCD40 ligandMurine modelB cellsTerm engraftmentBlockadeEngraftment