2024
Image-based 3D genomics through chromatin tracing
Yang T, Wang S. Image-based 3D genomics through chromatin tracing. Nature Reviews Methods Primers 2024, 4: 76. DOI: 10.1038/s43586-024-00354-y.Peer-Reviewed Original ResearchChromatin tracingChromatin organizationHigh-throughput sequencing-based methodsRegulation of gene expressionSequencing-based methodsSingle-cellGenetic screening technologiesGenome foldingGenomic scaleGenome functionChromatin labelingGenomic levelSpectrum of cell typesDNA replicationModel organismsChromatinGene expressionIntact cellsSystematic profilingSingle-molecule levelCell typesGenomeScreening technologiesFilling major gapsPrimers
2016
Spatial organization of chromatin domains and compartments in single chromosomes
Wang S, Su JH, Beliveau BJ, Bintu B, Moffitt JR, Wu CT, Zhuang X. Spatial organization of chromatin domains and compartments in single chromosomes. Science 2016, 353: 598-602. PMID: 27445307, PMCID: PMC4991974, DOI: 10.1126/science.aaf8084.Peer-Reviewed Original ResearchConceptsIndividual chromosomesChromatin domainsX chromosomeNumerous genomic regionsSpatial organizationInactive X chromosomeGenome functionChromatin organizationGenomic regionsFractal globule modelSingle chromosomePolarized mannerChromosomesDifferent foldingTADCompartmentsAutosomesChromatinDomainTADsFoldingRegulationCapture studies