2023
The Ethics of Risk Prediction for Psychosis and Suicide Attempt in Youth Mental Health
Smith W, Appelbaum P, Lebowitz M, Gülöksüz S, Calkins M, Kohler C, Gur R, Barzilay R. The Ethics of Risk Prediction for Psychosis and Suicide Attempt in Youth Mental Health. The Journal Of Pediatrics 2023, 263: 113583. PMID: 37353146, PMCID: PMC10828819, DOI: 10.1016/j.jpeds.2023.113583.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentArtificial IntelligenceHumansMental HealthPsychotic DisordersRisk FactorsSuicide, AttemptedConceptsEthical implicationsDistinct ethical challengesEthical challengesEthicsInformed consentBroader discussionPolygenic risk scoresClinical utilityRisk scoreSuicide attemptsQuestionsYouth mental health settingsRisk-benefit balancePopulation-level screeningConsumer advertisingPotential clinical utilityMental health settingsAttemptConsentClinical questionsPredictive scoreHealth settingsNarrative literature reviewImplicationsLiterature review
2022
Early intervention service systems for youth mental health: integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis
Shah J, Jones N, van Os J, McGorry P, Gülöksüz S. Early intervention service systems for youth mental health: integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis. The Lancet Psychiatry 2022, 9: 413-422. PMID: 35430004, DOI: 10.1016/s2215-0366(21)00467-3.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentEarly Intervention, EducationalEarly Medical InterventionHumansMental HealthPsychotic DisordersSyndromeConceptsRisk mental stateBroader mental health systemNon-psychotic disordersPerson-centred careMental health systemYouth mental healthClinical stagingEarly intervention service systemFirst episodeRelevance of outcomesEarly psychosisCenters of expertiseFrequent developmentDifferential riskClinical researchHealth systemPsychosisSpecific interventionsMental healthSyndromeMental statesDisordersTraditional diagnosisOutcomesClinic
2020
Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia
Pries L, van Os J, Have M, de Graaf R, van Dorsselaer S, Bak M, Lin B, van Eijk K, Kenis G, Richards A, O’Donovan M, Luykx J, Rutten B, Guloksuz S. Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia. JAMA Psychiatry 2020, 77: 1296-1304. PMID: 32805017, PMCID: PMC7711318, DOI: 10.1001/jamapsychiatry.2020.2304.Peer-Reviewed Original ResearchConceptsRecent stressful life eventsStressful life eventsAssociations of SLEsPoor physical healthMental health outcomesHealth outcomesPhysical healthGeneral populationPopulation-based prospective cohort studyPRS-SCZNetherlands Mental Health SurveyES-SCZMental healthProspective cohort studyIncidence Study-2Modifiable environmental factorsAdulthood stressful life eventsMental Health SurveyDutch general populationPoor mental healthPopulation-based health outcomesLife eventsCohort studyMean ageHealth Survey