Sierra Dawn Kauer
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Featured Publications
PAK1 inhibition with Romidepsin attenuates H‐reflex hyperexcitability after spinal cord injury
Kauer S, Benson C, Carrara J, Tarafder A, Ibrahim Y, Estacion M, Waxman S, Tan A. PAK1 inhibition with Romidepsin attenuates H‐reflex hyperexcitability after spinal cord injury. The Journal Of Physiology 2024, 602: 5061-5081. PMID: 39231098, DOI: 10.1113/jp284976.Peer-Reviewed Original ResearchDendritic spine dysgenesisSpinal cord injurySCI-induced spasticityRomidepsin treatmentSpine dysgenesisLoss of rate-dependent depressionCutaneous T-cell lymphomaTreatment of cutaneous T-cell lymphomaContusive spinal cord injuryT-cell lymphomaSpinal cord injury animalsCord injuryRate-dependent depressionExaggerated reflex responsesH-reflex changesSpinal cord injury mouse modelManaging spasticityReduce spasticityReporter micePreclinical utilityDrug responseRomidepsinControl cohortIntervention effectsSpinal hyperreflexia
2024
A FAIR, open-source virtual reality platform for dendritic spine analysis
Reimer M, Kauer S, Benson C, King J, Patwa S, Feng S, Estacion M, Bangalore L, Waxman S, Tan A. A FAIR, open-source virtual reality platform for dendritic spine analysis. Patterns 2024, 5: 101041. PMID: 39568639, PMCID: PMC11573899, DOI: 10.1016/j.patter.2024.101041.Peer-Reviewed Original ResearchVirtual realityVirtual reality platformSoftware ecosystemReality platformData standardSuperior accuracyDatasetWorkflowValidation processDendritic spine morphologySpine analysisDendritic spinesReconstruction techniqueSpine lengthMethod's superior accuracyDendritic spine lengthSpine morphologyMetricsMorphological metricsNeurodataFairness
2023
Conditional Astrocyte Rac1KO Attenuates Hyperreflexia after Spinal Cord Injury
Benson C, Olson K, Patwa S, Kauer S, King J, Waxman S, Tan A. Conditional Astrocyte Rac1KO Attenuates Hyperreflexia after Spinal Cord Injury. Journal Of Neuroscience 2023, 44: e1670222023. PMID: 37963762, PMCID: PMC10851682, DOI: 10.1523/jneurosci.1670-22.2023.Peer-Reviewed Original ResearchConceptsSpinal cord injuryRate-dependent depressionΑ-motor neuronsGlutamate transporter 1Dendritic spine dysgenesisCord injurySpine dysgenesisDevelopment of SCIMild contusion spinal cord injuryAstrocytic glutamate transporter 1Glial-specific glutamate transporterContusion spinal cord injuryTransporter 1Development of hyperreflexiaMonosynaptic H-reflexDendritic spine densityPre-injury levelSpinal reflex circuitsVentral spinal cordReflex hyperexcitabilityHyperexcitability disordersFunctional recoveryGlutamate clearanceH-reflexVentral hornIncreased astrocytic GLT-1 expression in tripartite synapses is associated with SCI-induced hyperreflexia
Benson C, King J, Kauer S, Waxman S, Tan A. Increased astrocytic GLT-1 expression in tripartite synapses is associated with SCI-induced hyperreflexia. Journal Of Neurophysiology 2023, 130: 1358-1366. PMID: 37877184, PMCID: PMC10972632, DOI: 10.1152/jn.00234.2023.Peer-Reviewed Original ResearchConceptsSpinal cord injuryRate-dependent depressionTripartite synapsesGLT-1Astrocytic GLT-1 expressionChronic neurological complicationsGLT-1 expressionAstrocyte involvementChronic spasticityUninjured shamsNeurological complicationsNeuropathic painHyperexcitability disordersH-reflexPSD-95 proteinReactive astrocytesVentral hornCord injuryMuscle toneAstrocytes' roleSpinal cordSpinal circuitsSynaptic transmissionHyperreflexiaSpasticityAnatomical Diversity of the Adult Corticospinal Tract Revealed by Single-Cell Transcriptional Profiling
Golan N, Ehrlich D, Bonanno J, O'Brien R, Murillo M, Kauer S, Ravindra N, Van Dijk D, Cafferty W. Anatomical Diversity of the Adult Corticospinal Tract Revealed by Single-Cell Transcriptional Profiling. Journal Of Neuroscience 2023, 43: 7929-7945. PMID: 37748862, PMCID: PMC10669816, DOI: 10.1523/jneurosci.0811-22.2023.Peer-Reviewed Original ResearchConceptsCorticospinal tract neuronsCorticospinal tractAdult corticospinal tractIrreversible functional deficitsCortical layer 2/3Lumbar spinal cordSpinal cord injuryLayer 5 neuronsClasses of neuronsMolecular heterogeneityAxon collateralizationTract neuronsCord injuryRetrograde labelingMotor pathwaysFemale miceFunctional deficitsLayer 2/3Primary axonsSpinal cordTerminal fieldsNeuron subtypesAdult tractTherapeutic interventionsSingle-cell RNA sequencing
2022
Dendritic Spines and Pain Memory
Benson C, King J, Reimer M, Kauer S, Waxman S, Tan A. Dendritic Spines and Pain Memory. The Neuroscientist 2022, 30: 294-314. PMID: 36461773, DOI: 10.1177/10738584221138251.Peer-Reviewed Original ResearchNeuropathic painDendritic spinesSynaptic transmissionSpinal cord dorsal hornForm of painNew therapeutic approachesSurface of neuronsDorsal hornIntractable painDeep laminaePain memoryTherapeutic approachesPainNervous systemNew therapeuticsSpineMillions of peopleInjuryDiseaseRecent studiesReview articlePrevalenceNeuronsImportant roleInositol Polyphosphate-5-Phosphatase K (Inpp5k) Enhances Sprouting of Corticospinal Tract Axons after CNS Trauma
Kauer SD, Fink KL, Li EHF, Evans BP, Golan N, Cafferty W. Inositol Polyphosphate-5-Phosphatase K (Inpp5k) Enhances Sprouting of Corticospinal Tract Axons after CNS Trauma. Journal Of Neuroscience 2022, 42: 2190-2204. PMID: 35135857, PMCID: PMC8936595, DOI: 10.1523/jneurosci.0897-21.2022.Peer-Reviewed Original ResearchConceptsAdult corticospinal neuronsSpinal cord injuryCorticospinal neuronsCNS neuronsAxon growthCNS traumaCord injuryCorticospinal tractAdult CNS environmentChronic functional deficitsConcomitant functional recoveryCorticospinal tract neuronsNogo receptor 1Corticospinal tract axonsRetinal ganglion cellsRobust axon growthEmbryonic cortical neuronsEmbryonic CNS neuronsCortical strokeContusion injuryNeurologic recoveryTract neuronsSpinal contusionFunctional recoveryCST axons
2020
Pericytes improve locomotor recovery after spinal cord injury in male and female neonatal rats
Mayo J, Kauer S, Brumley M, Bearden S. Pericytes improve locomotor recovery after spinal cord injury in male and female neonatal rats. Microcirculation 2020, 27: e12646. PMID: 32608116, DOI: 10.1111/micc.12646.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBlood Flow VelocityCell- and Tissue-Based TherapyCell ProliferationCell SurvivalCells, CulturedDisease Models, AnimalFemaleHeterograftsHindlimbHumansLocomotionMaleNeovascularization, PhysiologicPericytesRatsRecovery of FunctionSex FactorsSpinal CordSpinal Cord InjuriesConceptsSpinal cord injuryCord injuryVascular densityImproved motor function recoveryHindlimb motor recoveryMotor function recoveryFemale neonatal ratsRecovery post-SCIPostnatal day threeSite of injurySite of transectionBlood flow perfusionGreater vascular densityHypoxia-inducible factor (HIF) pathwayMotor recoveryLocomotor recoveryNeonatal modelPost-SCIFunction recoveryNew capillary growthNeonatal ratsAcute deliveryMotor functionSpinal cordRat pups
2017
Stimulation of 5-HT2A Receptors Recovers Sensory Responsiveness in Acute Spinal Neonatal Rats
Swann H, Kauer S, Allmond J, Brumley M. Stimulation of 5-HT2A Receptors Recovers Sensory Responsiveness in Acute Spinal Neonatal Rats. Behavioral Neuroscience 2017, 131: 92-98. PMID: 28004950, PMCID: PMC5269442, DOI: 10.1037/bne0000176.Peer-Reviewed Original ResearchConceptsSpinal cord injurySpinal ratsTail pinchMotor activityCord injurySensory stimulationNeonatal ratsSensory afferent stimulationRecovery of functionHind limb movementsTail pinchingAfferent stimulationReceptor agonistSpinal cordRat pupsAdult rodentsMotor circuitsQuipazineSupine postureRatsBaseline periodIntact levelsLevel of activityStimulationInjury
2016
Maternal behavior influences development of a reflexive action pattern in the newborn rat
Kauer S, Allmond J, Belnap S, Brumley M. Maternal behavior influences development of a reflexive action pattern in the newborn rat. Developmental Psychobiology 2016, 58: 1043-1054. PMID: 27279291, DOI: 10.1002/dev.21438.Peer-Reviewed Original ResearchConceptsLeg extension responseIntranasal applicationRat pupsMaternal behaviorAnogenital lickingMaternal anogenital lickingPostnatal day 9Neonatal ratsPregnant damsPerinatal periodNewborn ratsAnkle anglePostnatal developmentDay 9PupsMaternal careRatsBehavioral developmentReflexive behaviorZinc sulfateDaysVibrotactile deviceHyperextensionIncidence