2021
Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development
Xia S, VanKuren NW, Chen C, Zhang L, Kemkemer C, Shao Y, Jia H, Lee U, Advani AS, Gschwend A, Vibranovski MD, Chen S, Zhang YE, Long M. Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development. PLOS Genetics 2021, 17: e1009654. PMID: 34242211, PMCID: PMC8270118, DOI: 10.1371/journal.pgen.1009654.Peer-Reviewed Original ResearchConceptsNew genesPhenotypic effectsEssential functionsLong evolutionary time scalesDevelopment of DrosophilaEvolutionary time scalesDrosophila developmentDrosophila genusEssential genesGene essentialityRNAi libraryYoung genesGenomic analysisCRISPR knockoutKnockout approachGenetic basisKnockdown experimentsComputational identificationGene effectsGenesDuplicate copiesRapid evolutionDrosophilaKnockdown efficiencyDistant ancestors
2013
New Gene Evolution: Little Did We Know
Long M, VanKuren NW, Chen S, Vibranovski MD. New Gene Evolution: Little Did We Know. Annual Review Of Genetics 2013, 47: 307-333. PMID: 24050177, PMCID: PMC4281893, DOI: 10.1146/annurev-genet-111212-133301.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainDrosophila melanogasterEvolution, MolecularForecastingGene DosageGene DuplicationGene Expression RegulationGene Regulatory NetworksGene Transfer, HorizontalGenesGenes, InsectGenes, PlantGenetic StructuresHumansMammalsModels, GeneticPhenotypePhylogenyRecombination, GeneticRNA, UntranslatedSelection, GeneticSex CharacteristicsTranscription, GeneticConceptsNew gene originationNew genesGene originationGenetic systemNew gene evolutionNew gene structuresGene evolutionPhenotypic evolutionGene structureDifferent organismsBiological diversityPhenotypic functionsGenesGenomeOriginationEvolutionDecades of effortOrganismsDiversityComprehensive pictureCritical component
2012
Frequent Recent Origination of Brain Genes Shaped the Evolution of Foraging Behavior in Drosophila
Chen S, Spletter M, Ni X, White KP, Luo L, Long M. Frequent Recent Origination of Brain Genes Shaped the Evolution of Foraging Behavior in Drosophila. Cell Reports 2012, 1: 118-132. PMID: 22832161, PMCID: PMC4382513, DOI: 10.1016/j.celrep.2011.12.010.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAgingAmino Acid SequenceAnimalsArthropod AntennaeBrainDrosophila melanogasterDrosophila ProteinsEvolution, MolecularFeeding BehaviorFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalGenes, InsectMaleMolecular Sequence DataMushroom BodiesNeuronsSelection, GeneticSex CharacteristicsSynaptic TransmissionTranscriptomeConceptsNew genesForaging behaviorMushroom bodiesYoung retrogenesAdaptive evolutionPhenotypic evolutionEvolutionary signaturesYoung genesNatural selectionGenetic basisBrain genesExpression profilingComparative behavioral analysisBrain evolutionGenesOlfactory circuitDrosophilaNew functionsAnimal behaviorNeuronal expressionExpressionRetrogenesNeural circuitsEvolutionRecent evolution
2011
Roles of young serine-endopeptidase genes in survival and reproduction revealed rapid evolution of phenotypic effects at adult stages
Chen S, Yang H, Krinsky BH, Zhang A, Long M. Roles of young serine-endopeptidase genes in survival and reproduction revealed rapid evolution of phenotypic effects at adult stages. Fly 2011, 5: 345-351. PMID: 21946255, PMCID: PMC3266076, DOI: 10.4161/fly.5.4.17808.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDrosophila melanogasterDrosophila ProteinsEvolution, MolecularGene DuplicationLongevityPhenotypeReproductionSerine EndopeptidasesConceptsYoung genesConstitutive knockdownAdult stageD. melanogaster subgroupEvolution of developmentImportant functional roleMelanogaster subgroupDrosophila melanogasterLethal phenotypeNew genesCommon ancestorImportant traitsNatural selectionEndopeptidase genePhenotypic effectsLife historyWildtype levelsMultiple phenotypesGenesFunctional roleGenetic componentRapid evolutionMale fertilityFemale fertilityKnockdownHighly Tissue Specific Expression of Sphinx Supports Its Male Courtship Related Role in Drosophila melanogaster
Chen Y, Dai H, Chen S, Zhang L, Long M. Highly Tissue Specific Expression of Sphinx Supports Its Male Courtship Related Role in Drosophila melanogaster. PLOS ONE 2011, 6: e18853. PMID: 21541324, PMCID: PMC3082539, DOI: 10.1371/journal.pone.0018853.Peer-Reviewed Original ResearchMeSH KeywordsAnimal StructuresAnimalsBase PairingBase SequenceBrainConserved SequenceCourtshipDrosophila melanogasterFemaleGene Expression ProfilingGene Expression RegulationGenome, InsectGreen Fluorescent ProteinsMaleMolecular Sequence DataMutationOrgan SpecificityPeripheral Nervous SystemPromoter Regions, GeneticRNA, UntranslatedSexual Behavior, AnimalTransformation, GeneticConceptsDrosophila melanogasterBp regionCourtship behaviorNon-coding RNA genesWhole genome expression profilingBp upstream regionTissue-specific expressionGenome expression profilingMale courtship behaviorMale accessory glandsMelanogaster subgroupDrosophila speciesD. virilisRNA genesGene categoriesProtein functionKnockout mutationsWing hairsMale courtshipTarget genesExpression profilingGFP signalNegative regulatorEnhancer elementsExpression signals
2010
New Genes in Drosophila Quickly Become Essential
Chen S, Zhang YE, Long M. New Genes in Drosophila Quickly Become Essential. Science 2010, 330: 1682-1685. PMID: 21164016, PMCID: PMC7211344, DOI: 10.1126/science.1196380.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAnimalsBody PatterningDrosophilaDrosophila melanogasterDrosophila ProteinsEvolution, MolecularGene DuplicationGene Expression ProfilingGene Expression Regulation, DevelopmentalGenes, EssentialGenes, InsectLarvaMetamorphosis, BiologicalPhenotypePhylogenyPupaRNA InterferenceTime FactorsWings, Animal
2008
The evolution of courtship behaviors through the origination of a new gene in Drosophila
Dai H, Chen Y, Chen S, Mao Q, Kennedy D, Landback P, Eyre-Walker A, Du W, Long M. The evolution of courtship behaviors through the origination of a new gene in Drosophila. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 7478-7483. PMID: 18508971, PMCID: PMC2396706, DOI: 10.1073/pnas.0800693105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological EvolutionCourtshipDrosophila melanogasterGenes, InsectMaleMutationPhenotypeRNA, AntisenseSexual Behavior, AnimalTranscription, GeneticConceptsMale-male courtshipD. melanogasterChimeric geneCourtship behaviorNew genesRelated Drosophila speciesNew chimeric genesDrosophila speciesAdaptive evolutionMutant phenotypeDrosophila melanogasterAncestral conditionUnrelated genesPhenotypic effectsMelanogasterNovel phenotypesCombination of sequenceMating behaviorChimeric structureGenesCourtshipSpeciesPhenotypeDrosophilaKnockout