Advances in Ischemia Reperfusion Injury Prevention in Free Flaps and Vascularized Composite Allotransplantation
Hadzimustafic N, D’Elia A, Duru C, Haykal S. Advances in Ischemia Reperfusion Injury Prevention in Free Flaps and Vascularized Composite Allotransplantation. 2024, 4 DOI: 10.5772/intechopen.112993.Peer-Reviewed Original ResearchIschemia-reperfusion injuryVascularized composite allotransplantationFree flapsStatic cold storagePharmacological strategiesAdvanced reconstructive optionsAttenuation of ischemia-reperfusion injuryIrreversible ischemic damagePost-operative monitoringStem cell strategiesPre-clinical studiesPlastic and Reconstructive SurgeryPost-ischemic periodPost-ischemicReperfusion injuryReconstructive optionsIschemia-reperfusionPre-ischemicReconstructive surgeryIschemic periodPre-ischemic periodIschemic damageClinical toolFlapMachine perfusionBioengineering of vascularized porcine flaps using perfusion-recellularization
Xu M, D’Elia A, Hadzimustafic N, Adil A, Karoubi G, Waddell T, Haykal S. Bioengineering of vascularized porcine flaps using perfusion-recellularization. Scientific Reports 2024, 14: 7590. PMID: 38555385, PMCID: PMC10981729, DOI: 10.1038/s41598-024-58095-7.Peer-Reviewed Original ResearchConceptsLow-concentration sodium dodecyl sulfateAcellular scaffoldsRecellularization techniquesPerfusion-decellularizationMesenchymal stromal cellsSodium dodecyl sulfateCell attachmentRecellularization approachCo-culture of human umbilical vein endothelial cellsRecellularizationHuman umbilical vein endothelial cellsReconstructive surgeryTensor fasciae lataeExtracellular matrixRepair optionsDonor site morbidityImpact patient qualityDodecyl sulfateClinically translatable optionTensor fascia lata flapUmbilical vein endothelial cellsSoft tissue defectsPorcine flaps