Integrated Analysis of Blood and Urine Biomarkers to Identify Acute Kidney Injury Subphenotypes and Associations With Long-term Outcomes
Bhatraju P, Prince D, Mansour S, Ikizler T, Siew E, Chinchilli V, Garg A, Go A, Kaufman J, Kimmel P, Coca S, Parikh C, Wurfel M, Himmelfarb J. Integrated Analysis of Blood and Urine Biomarkers to Identify Acute Kidney Injury Subphenotypes and Associations With Long-term Outcomes. American Journal Of Kidney Diseases 2023, 82: 311-321.e1. PMID: 37178093, PMCID: PMC10523857, DOI: 10.1053/j.ajkd.2023.01.449.Peer-Reviewed Original ResearchConceptsMajor adverse kidney eventsLong-term outcomesAKI subphenotypesKidney injuryClinical outcomesUrinary biomarkersHigh riskChronic kidney disease progressionLong-term clinical outcomesCox proportional hazards modelAdverse kidney eventsLong-term sequalaeHospital-level factorsKidney disease progressionChronic kidney diseaseKaplan-Meier curvesSerum creatinine concentrationEpithelial cell injuryHeterogeneous clinical syndromeProportional hazards modelLong-term riskAKI patientsAKI subgroupKDIGO stageMedian follow