2012
The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub
Trofka A, Schwendinger-Schreck J, Brend T, Pontius W, Emonet T, Holley SA. The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub. Development 2012, 139: 940-947. PMID: 22278920, PMCID: PMC3274355, DOI: 10.1242/dev.073544.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasic Helix-Loop-Helix Transcription FactorsBiological ClocksBody PatterningComputer SimulationDimerizationDNAGene Expression Regulation, DevelopmentalGene Knockdown TechniquesGene Regulatory NetworksRecombinant Fusion ProteinsRepressor ProteinsTranscription FactorsZebrafishZebrafish ProteinsConceptsZebrafish segmentation clockSegmentation clockBinds DNACis-regulatory sequencesDNA-binding heterodimersTranscriptional negative feedbackGenetic experimentsHer7Regulatory sequencesDNA bindingHes6Vivo assaysDNAHomodimerHeterodimersDistinct preferenceEmergent functionsNetwork hubsNegative feedbackComputational analysisClockDimersSequestrationProteinRegulation
2005
beamter/deltaC and the role of Notch ligands in the zebrafish somite segmentation, hindbrain neurogenesis and hypochord differentiation
Jülich D, Lim C, Round J, Nicolaije C, Schroeder J, Davies A, Geisler R, Lewis J, Jiang Y, Holley S, Consortium T. beamter/deltaC and the role of Notch ligands in the zebrafish somite segmentation, hindbrain neurogenesis and hypochord differentiation. Developmental Biology 2005, 286: 391-404. PMID: 16125692, DOI: 10.1016/j.ydbio.2005.06.040.Peer-Reviewed Original ResearchConceptsPresomitic mesodermSomite segmentationZebrafish genetic screenEGF repeatsGenetic screenOscillating expressionOscillating genesSegmentation clockDouble mutantDSL domainSubcellular localizationAntimorphic effectsStrong defectsGene expressionNotch pathwayNotch ligandsNew allelesIndividual cellsDeltaCTriple fluorescentCoordinated oscillationsGenesAllelesExpressionLigand functions