Featured Publications
Cross-Scale Integrin Regulation Organizes ECM and Tissue Topology
Jülich D, Cobb G, Melo AM, McMillen P, Lawton AK, Mochrie SG, Rhoades E, Holley SA. Cross-Scale Integrin Regulation Organizes ECM and Tissue Topology. Developmental Cell 2015, 34: 33-44. PMID: 26096733, PMCID: PMC4496283, DOI: 10.1016/j.devcel.2015.05.005.Peer-Reviewed Original ResearchConceptsExtracellular matrixCadherin-2Integrin α5Cell-cell adhesionFluorescence cross-correlation spectroscopyECM protein fibronectinSomite boundariesCross-correlation spectroscopyAdjacent cell membranesBody elongationECM assemblyIntegrin associationIntegrin activationPhysical associationActive conformationFibronectin fibrillogenesisProtein fibronectinTissue assemblyIntegrin conformationTissue topologyInactive integrinsCell membraneCross-scale mechanismsStereotypic patternAnimal tissues
2016
A Sawtooth Pattern of Cadherin 2 Stability Mechanically Regulates Somite Morphogenesis
McMillen P, Chatti V, Jülich D, Holley SA. A Sawtooth Pattern of Cadherin 2 Stability Mechanically Regulates Somite Morphogenesis. Current Biology 2016, 26: 542-549. PMID: 26853361, PMCID: PMC4822709, DOI: 10.1016/j.cub.2015.12.055.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCadherinsExtracellular MatrixMesodermMorphogenesisSomitesZebrafishZebrafish ProteinsConceptsECM assemblyGenetic mosaicsPosterior somitesDifferential cadherin expressionExtracellular matrixCell-ECM adhesionFN matrix assemblyBoundary formationVertebrate gastrulationSomite boundariesSomite morphogenesisCytoskeletal contractilityParaxial mesodermEmbryonic precursorsCDH activityMatrix assemblyCadherin expressionCDH2SomitesTissue boundariesIntegrin α5SomitogenesisCell sortingCell aggregatesAssembly
2013
Regulated tissue fluidity steers zebrafish body elongation
Lawton AK, Nandi A, Stulberg MJ, Dray N, Sneddon MW, Pontius W, Emonet T, Holley SA. Regulated tissue fluidity steers zebrafish body elongation. Development 2013, 140: 573-582. PMID: 23293289, PMCID: PMC3561786, DOI: 10.1242/dev.090381.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedBiomechanical PhenomenaBody PatterningCadherinsCell AdhesionCell CountCell MovementCell PolarityComputer SimulationEmbryo, NonmammalianEmbryonic DevelopmentFibroblast Growth FactorsGene Expression Regulation, DevelopmentalModels, BiologicalTailTime FactorsWnt Signaling PathwayZebrafishZebrafish Proteins