Featured Publications
Patterned Disordered Cell Motion Ensures Vertebral Column Symmetry
Das D, Chatti V, Emonet T, Holley SA. Patterned Disordered Cell Motion Ensures Vertebral Column Symmetry. Developmental Cell 2017, 42: 170-180.e5. PMID: 28743003, PMCID: PMC5568629, DOI: 10.1016/j.devcel.2017.06.020.Peer-Reviewed Original Research
2013
Cell-Fibronectin Interactions Propel Vertebrate Trunk Elongation via Tissue Mechanics
Dray N, Lawton A, Nandi A, Jülich D, Emonet T, Holley SA. Cell-Fibronectin Interactions Propel Vertebrate Trunk Elongation via Tissue Mechanics. Current Biology 2013, 23: 1335-1341. PMID: 23810535, PMCID: PMC3725194, DOI: 10.1016/j.cub.2013.05.052.Peer-Reviewed Original ResearchConceptsCell migrationTrunk elongationExtracellular matrixCell-FN interactionsTransgenic rescue experimentsECM protein fibronectinElongation defectsParaxial mesodermBody elongationEmbryonic developmentTissue homeostasisTail budTissue mechanicsΑ-subunitRescue experimentsProtein fibronectinSystem-level analysisCell adhesionFN matrixIntegrin α5Concomitant lossTissue integrityCell motionITGαvFibronectinRegulated tissue fluidity steers zebrafish body elongation
Lawton AK, Nandi A, Stulberg MJ, Dray N, Sneddon MW, Pontius W, Emonet T, Holley SA. Regulated tissue fluidity steers zebrafish body elongation. Development 2013, 140: 573-582. PMID: 23293289, PMCID: PMC3561786, DOI: 10.1242/dev.090381.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedBiomechanical PhenomenaBody PatterningCadherinsCell AdhesionCell CountCell MovementCell PolarityComputer SimulationEmbryo, NonmammalianEmbryonic DevelopmentFibroblast Growth FactorsGene Expression Regulation, DevelopmentalModels, BiologicalTailTime FactorsWnt Signaling PathwayZebrafishZebrafish Proteins
2012
Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud
Stulberg MJ, Lin A, Zhao H, Holley SA. Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud. Developmental Biology 2012, 369: 298-307. PMID: 22796649, PMCID: PMC3423502, DOI: 10.1016/j.ydbio.2012.07.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceDNA PrimersFibroblast Growth FactorsGene Expression Regulation, DevelopmentalGene Regulatory NetworksGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaMAP Kinase Signaling SystemModels, BiologicalPhosphatidylinositol 3-KinasesPhosphorylationProto-Oncogene Proteins c-aktSignal TransductionTailWnt Signaling PathwayZebrafishZebrafish ProteinsConceptsZebrafish tailbudCell fate specificationCell fate changesCo-regulated genesWnt antagonist Dkk1Reciprocal positive regulationFate specificationFate changesNascent transcriptionAxis elongationProtein phosphorylationPhosphorylation of GSK3βPI3-kinaseFGF pathwayMesodermal developmentTail elongationPositive regulationTarget genesAntagonist DKK1TailbudFibroblast growth factorWntPhosphorylation levelsTranscriptionGSK3β phosphorylation