Cross-Scale Integrin Regulation Organizes ECM and Tissue Topology
Jülich D, Cobb G, Melo AM, McMillen P, Lawton AK, Mochrie SG, Rhoades E, Holley SA. Cross-Scale Integrin Regulation Organizes ECM and Tissue Topology. Developmental Cell 2015, 34: 33-44. PMID: 26096733, PMCID: PMC4496283, DOI: 10.1016/j.devcel.2015.05.005.Peer-Reviewed Original ResearchConceptsExtracellular matrixCadherin-2Integrin α5Cell-cell adhesionFluorescence cross-correlation spectroscopyECM protein fibronectinSomite boundariesCross-correlation spectroscopyAdjacent cell membranesBody elongationECM assemblyIntegrin associationIntegrin activationPhysical associationActive conformationFibronectin fibrillogenesisProtein fibronectinTissue assemblyIntegrin conformationTissue topologyInactive integrinsCell membraneCross-scale mechanismsStereotypic patternAnimal tissues