Featured Publications
Cross-Scale Integrin Regulation Organizes ECM and Tissue Topology
Jülich D, Cobb G, Melo AM, McMillen P, Lawton AK, Mochrie SG, Rhoades E, Holley SA. Cross-Scale Integrin Regulation Organizes ECM and Tissue Topology. Developmental Cell 2015, 34: 33-44. PMID: 26096733, PMCID: PMC4496283, DOI: 10.1016/j.devcel.2015.05.005.Peer-Reviewed Original ResearchConceptsExtracellular matrixCadherin-2Integrin α5Cell-cell adhesionFluorescence cross-correlation spectroscopyECM protein fibronectinSomite boundariesCross-correlation spectroscopyAdjacent cell membranesBody elongationECM assemblyIntegrin associationIntegrin activationPhysical associationActive conformationFibronectin fibrillogenesisProtein fibronectinTissue assemblyIntegrin conformationTissue topologyInactive integrinsCell membraneCross-scale mechanismsStereotypic patternAnimal tissues
2013
Cell-Fibronectin Interactions Propel Vertebrate Trunk Elongation via Tissue Mechanics
Dray N, Lawton A, Nandi A, Jülich D, Emonet T, Holley SA. Cell-Fibronectin Interactions Propel Vertebrate Trunk Elongation via Tissue Mechanics. Current Biology 2013, 23: 1335-1341. PMID: 23810535, PMCID: PMC3725194, DOI: 10.1016/j.cub.2013.05.052.Peer-Reviewed Original ResearchConceptsCell migrationTrunk elongationExtracellular matrixCell-FN interactionsTransgenic rescue experimentsECM protein fibronectinElongation defectsParaxial mesodermBody elongationEmbryonic developmentTissue homeostasisTail budTissue mechanicsΑ-subunitRescue experimentsProtein fibronectinSystem-level analysisCell adhesionFN matrixIntegrin α5Concomitant lossTissue integrityCell motionITGαvFibronectin