Featured Publications
Fibronectin is a smart adhesive that both influences and responds to the mechanics of early spinal column development
Guillon E, Das D, Jülich D, Hassan AR, Geller H, Holley S. Fibronectin is a smart adhesive that both influences and responds to the mechanics of early spinal column development. ELife 2020, 9: e48964. PMID: 32228864, PMCID: PMC7108867, DOI: 10.7554/elife.48964.Peer-Reviewed Original ResearchConceptsNeural tubeParaxial mesodermZebrafish neural tubeNormal vertebrate developmentVertebrate trunkVertebrate developmentFibronectin remodelingFibronectin matrixConvergence defectsMorphogenesisExtracellular matrixMesodermFibronectinColumn developmentSmart adhesivesCadherinMutantsAdhesive lap jointsAdhesionLap jointsSymmetric interfacesRemodelingShear stressDefects
2024
Live imaging of Fibronectin 1a-mNeonGreen and Fibronectin 1b-mCherry knock-in alleles during early zebrafish development
Jülich D, Holley S. Live imaging of Fibronectin 1a-mNeonGreen and Fibronectin 1b-mCherry knock-in alleles during early zebrafish development. Cells And Development 2024, 177: 203900. PMID: 38218338, PMCID: PMC10947920, DOI: 10.1016/j.cdev.2024.203900.Peer-Reviewed Original ResearchKnock-in alleleECM fibersLoss of function phenotypesGenetic complementation experimentsAdhesion receptor familyComplementation experimentsDouble mutantLive in vivo imagingExtracellular matrix glycoproteinFibronectin matrixPosterior hindgutPresomitic mesodermZebrafish developmentExpression patternsMRNA injectionIntegrinLive imagingCross-regulationAllelesFibronectinReceptor familyParaxial mesodermCo-localizationExtracellular matrixMutants
2013
Cell-Fibronectin Interactions Propel Vertebrate Trunk Elongation via Tissue Mechanics
Dray N, Lawton A, Nandi A, Jülich D, Emonet T, Holley SA. Cell-Fibronectin Interactions Propel Vertebrate Trunk Elongation via Tissue Mechanics. Current Biology 2013, 23: 1335-1341. PMID: 23810535, PMCID: PMC3725194, DOI: 10.1016/j.cub.2013.05.052.Peer-Reviewed Original ResearchConceptsCell migrationTrunk elongationExtracellular matrixCell-FN interactionsTransgenic rescue experimentsECM protein fibronectinElongation defectsParaxial mesodermBody elongationEmbryonic developmentTissue homeostasisTail budTissue mechanicsΑ-subunitRescue experimentsProtein fibronectinSystem-level analysisCell adhesionFN matrixIntegrin α5Concomitant lossTissue integrityCell motionITGαvFibronectin