Treatment delays in laryngeal squamous cell carcinoma: A national cancer database analysis
Morse E, Fujiwara RJT, Judson B, Mehra S. Treatment delays in laryngeal squamous cell carcinoma: A national cancer database analysis. The Laryngoscope 2018, 128: 2751-2758. PMID: 29756382, DOI: 10.1002/lary.27247.Peer-Reviewed Original ResearchConceptsLaryngeal squamous cell carcinomaOverall survivalSquamous cell carcinomaTreatment initiationNonsurgical patientsSurgical patientsTotal treatment packageMedian durationRadiation treatmentTreatment delayCell carcinomaTreatment endNational Cancer Database AnalysisEnd intervalCox proportional hazards regressionNational Cancer DatabaseProportional hazards regressionMultivariable logistic regressionDuration of diagnosisHigh-volume facilitiesTreatment packageRadiotherapy durationAdjuvant treatmentHazards regressionInsurance statusUpfront surgery versus definitive chemoradiotherapy in patients with human Papillomavirus-associated oropharyngeal squamous cell cancer
Kelly JR, Park HS, An Y, Yarbrough WG, Contessa JN, Decker R, Mehra S, Judson BL, Burtness B, Husain Z. Upfront surgery versus definitive chemoradiotherapy in patients with human Papillomavirus-associated oropharyngeal squamous cell cancer. Oral Oncology 2018, 79: 64-70. PMID: 29598952, DOI: 10.1016/j.oraloncology.2018.02.017.Peer-Reviewed Original ResearchConceptsNational Cancer DatabasePrimary surgeryOverall survivalAdjuvant chemoradiotherapyDefinitive chemoradiotherapyUpfront surgerySurgical patientsHuman papillomavirus-associated oropharyngeal squamous cell carcinomaOropharyngeal squamous cell carcinomaPropensity score-matched analysisOropharyngeal squamous cell cancerCox proportional hazards regressionMultivariable Cox regressionNon-private insuranceInferior overall survivalMargin-negative resectionSquamous cell cancerProportional hazards regressionSquamous cell carcinomaLog-rank testChi-square testClinicopathologic predictorsSimilar OSSurgery patientsTrimodal therapy