Featured Publications
Changes in Population-Level and Institutional-Level Prescribing Habits of Radioiodine Therapy for Papillary Thyroid Cancer
Jacobs D, Breen CT, Pucar D, Holt E, Judson BL, Mehra S. Changes in Population-Level and Institutional-Level Prescribing Habits of Radioiodine Therapy for Papillary Thyroid Cancer. Thyroid 2020, 31: 272-279. PMID: 32811347, DOI: 10.1089/thy.2020.0237.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerNational Cancer DatabaseThyroid cancerRadioactive iodine therapyNumber of patientsHospital-specific effectsIodine therapyAdvanced diseaseTotal thyroidectomyRadioiodine therapyPrescribing habitsRAI useCancer DatabaseMixed regression modelsPatientsJoinpoint analysisHospitalIndividual hospitalsCancerHospital selectionNational trendsThyroidectomyTherapySignificant declineRegression modelsPositive margin rates and predictors in transoral robotic surgery after federal approval: A national quality study
Hanna J, Morse E, Brauer PR, Judson B, Mehra S. Positive margin rates and predictors in transoral robotic surgery after federal approval: A national quality study. Head & Neck 2019, 41: 3064-3072. PMID: 31058417, DOI: 10.1002/hed.25792.Peer-Reviewed Original ResearchConceptsPositive margin rateTransoral robotic surgeryLow positive margin rateLow-volume facilitiesHigh-volume facilitiesPositive marginsT classificationMargin rateHuman papilloma virus (HPV) statusRobotic surgeryLymph-vascular invasionNational Cancer DatabaseMargin statusRetrospective reviewTumor subsiteVirus statusCancer DatabaseMultivariable regressionLinear associationPatientsSurgeryQuality studiesStatusAssociation
2024
Patterns of Care for T1 Glottic Squamous Cell Carcinomas from 2004–2020
Malik D, Jacobs D, Fereydooni S, Park H, Mehra S. Patterns of Care for T1 Glottic Squamous Cell Carcinomas from 2004–2020. The Laryngoscope 2024, 134: 3633-3644. PMID: 38411338, DOI: 10.1002/lary.31363.Peer-Reviewed Original ResearchGlottic squamous cell carcinomaT1 glottic squamous cell carcinomaSquamous cell carcinomaDual-modality treatmentOver-treatmentT1a tumorsCell carcinomaTreatment regimensOverall treatment modalityNational Cancer DatabaseRate of surgeryYear of treatmentMultivariate logistic regressionCochran-Armitage testT1b tumorsT1b diseaseCancer DatabaseOver-treatedTreatment modalitiesTreatment patternsAssociated with greater likelihoodSurgeryPatientsTumorLogistic regressionThe Impact of Four Smoking Metrics on Survival After Diagnosis with HPV+ Oropharyngeal Cancer
Wilkins S, Shah R, Safranek C, Shah H, Mehra S. The Impact of Four Smoking Metrics on Survival After Diagnosis with HPV+ Oropharyngeal Cancer. The Laryngoscope 2024, 134: 3158-3164. PMID: 38294283, DOI: 10.1002/lary.31319.Peer-Reviewed Original ResearchOropharyngeal squamous cell carcinomaRecurrence-free survivalHPV+ oropharyngeal squamous cell carcinomaOverall survivalPack-yearsTobacco useRetrospective review of patientsImpact overall survivalReview of patientsSquamous cell carcinomaSmoking metricsInferior OSImpact of tobacco useMetastatic diseaseImpact of smokingPrognostic significanceRetrospective reviewCell carcinomaSmoking historyUnivariate analysisNever-smokersMultivariate analysisSmoking statusPatientsInclusion criteria
2023
Role of PET/CT in Oropharyngeal Cancers
Avery E, Joshi K, Mehra S, Mahajan A. Role of PET/CT in Oropharyngeal Cancers. Cancers 2023, 15: 2651. PMID: 37174116, PMCID: PMC10177278, DOI: 10.3390/cancers15092651.Peer-Reviewed Original Research
2020
An Analysis of Otolaryngology Medical Malpractice Payments From the National Practitioner Data Bank
Breen CT, Mehra S. An Analysis of Otolaryngology Medical Malpractice Payments From the National Practitioner Data Bank. Otolaryngology 2020, 164: 589-594. PMID: 32691675, DOI: 10.1177/0194599820942498.Peer-Reviewed Original ResearchConceptsPatient ageNational Practitioner Data BankMalpractice paymentsRetrospective cross-sectional analysisMean paymentCross-sectional analysisInsignificant injuryBrain damageLifelong careMedian paymentPatientsNumber of otolaryngologistsMedical malpractice paymentsOtolaryngologistsInjurySeveritySignificant decreaseAgeAnnual numberDescriptive statisticsPayment amountAssociationYearsLinear regressionAssessment of Lymph Node Evaluation in Patients with Clinically Node Negative Merkel Cell Carcinoma of the Head and Neck
Jacobs D, Park H, Young M, Olino K, Rahmati R, Mehra S, Burtness B, Judson B. Assessment of Lymph Node Evaluation in Patients with Clinically Node Negative Merkel Cell Carcinoma of the Head and Neck. International Journal Of Radiation Oncology • Biology • Physics 2020, 106: 1191-1192. DOI: 10.1016/j.ijrobp.2019.11.099.Peer-Reviewed Original ResearchAdjuvant external beam radiotherapy for surgically resected, nonmetastatic anaplastic thyroid cancer
Saeed NA, Kelly JR, Deshpande HA, Bhatia AK, Burtness BA, Judson BL, Mehra S, Edwards HA, Yarbrough WG, Peter PR, Holt EH, Decker RH, Husain ZA, Park HS. Adjuvant external beam radiotherapy for surgically resected, nonmetastatic anaplastic thyroid cancer. Head & Neck 2020, 42: 1031-1044. PMID: 32011055, DOI: 10.1002/hed.26086.Peer-Reviewed Original ResearchConceptsAnaplastic thyroid cancerLonger OSAdjuvant EBRTThyroid cancerAdjuvant external beam radiotherapyNational Cancer DatabaseExternal beam radiotherapyConcurrent chemoradiationConcurrent chemotherapyImproved survivalMedian ageCancer DatabaseRetrospective analysisBeam radiotherapyEBRTChemotherapyPatientsCancerUVAChemoradiationResectionRadiotherapy
2019
Clinical Outcomes of Head and Neck Cancer Patients Who Undergo Resection, But Forgo Adjuvant Therapy
LOGANADANE G, KANN BH, PARK HS, JOHNSON SB, MEHRA S, JUDSON BL, BHATIA A, BELKACEMI Y, YARBROUGH WG, BURTNESS B, HUSAIN ZA. Clinical Outcomes of Head and Neck Cancer Patients Who Undergo Resection, But Forgo Adjuvant Therapy. Anticancer Research 2019, 39: 4885-4890. PMID: 31519591, DOI: 10.21873/anticanres.13674.Peer-Reviewed Original ResearchConceptsLocoregional recurrence-free survivalAdjuvant therapyNeck squamous cell carcinomaOutcomes of patientsRecurrence-free survivalSquamous cell carcinomaNeck cancer patientsHNSCC patientsClinical outcomesRecurrence rateCell carcinomaMean TTPCancer patientsPatientsTherapyResectionMonthsOutcomesHNSCCSurgeryCarcinomaHeadIncidenceProgressionPreoperative biopsy in parotid malignancies: Variation in use and impact on surgical margins
Benchetrit L, Torabi SJ, Morse E, Mehra S, Rahmati R, Osborn HA, Judson BL. Preoperative biopsy in parotid malignancies: Variation in use and impact on surgical margins. The Laryngoscope 2019, 130: 1450-1458. PMID: 31411749, DOI: 10.1002/lary.28224.Peer-Reviewed Original ResearchConceptsPreoperative biopsyParotid malignanciesSurgical marginsPositive marginsClinical T1 stageNational Cancer DatabaseClinical T stageClinical N stageHigh-volume centersSubgroup of patientsMultivariable logistic regressionEarly clinical stageChi-square testAdjuvant therapyRetrospective cohortYounger patientsT stageClinical stageSurgical outcomesVolume centersBiopsy useCancer DatabaseN stageBiopsyPatients
2018
A case of pediatric cervicofacial actinomyces masquerading as malignancy: Case report and review of the literature
Savoca E, Mehra S, Waldman EH. A case of pediatric cervicofacial actinomyces masquerading as malignancy: Case report and review of the literature. International Journal Of Pediatric Otorhinolaryngology 2018, 116: 204-208. PMID: 30554700, DOI: 10.1016/j.ijporl.2018.11.001.Peer-Reviewed Original ResearchConceptsAnterior neck massProlonged antibiotic courseFine needle aspiratesSix-week courseAntibiotic coursesOral penicillinSurgical debridementParenteral penicillinUncommon infectionMalignant appearanceNeck massOpen biopsyCase reportNeedle biopsyCulture sensitivityNeedle aspiratesBiopsyConvalescent therapyActinomycesDiagnosisPenicillinCase discussionDebridementPatientsMalignancyHypopharyngeal Cancer Treatment Delays: Benchmarks and Survival Association
Morse E, Berson E, Fujiwara R, Judson B, Mehra S. Hypopharyngeal Cancer Treatment Delays: Benchmarks and Survival Association. Otolaryngology 2018, 160: 267-276. PMID: 30324861, DOI: 10.1177/0194599818797605.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBenchmarkingCarcinoma, Squamous CellChemoradiotherapyCohort StudiesDisease-Free SurvivalFemaleHumansHypopharyngeal NeoplasmsLogistic ModelsMaleMiddle AgedMultivariate AnalysisPrognosisProportional Hazards ModelsRadiotherapy, ConformalRetrospective StudiesRisk AssessmentSurvival AnalysisTime-to-TreatmentTreatment OutcomeConceptsRadiation treatment durationOverall survivalInduction chemotherapyMedian durationConcurrent chemoradiationHypopharyngeal cancerCox proportional hazards regressionNational Cancer DatabaseProportional hazards regressionMultivariable logisticRetrospective cohortTreatment initiationMedicaid insuranceTreatment delayCancer HospitalHazards regressionNonwhite raceCancer DatabaseTreatment endSurvival associationsTreatment durationPatientsChemoradiationChemotherapyTreatment factorsPositive surgical margins in parotid malignancies: Institutional variation and survival association
Morse E, Fujiwara RJT, Judson B, Prasad ML, Mehra S. Positive surgical margins in parotid malignancies: Institutional variation and survival association. The Laryngoscope 2018, 129: 129-137. PMID: 30194762, DOI: 10.1002/lary.27221.Peer-Reviewed Original ResearchConceptsPositive surgical marginsPositive margin rateOverall survivalSurgical marginsHigh-volume facilitiesMargin ratePositive marginsParotid malignanciesMucoepidermoid carcinomaCox proportional hazards regressionOverall positive margin rateLow-grade mucoepidermoid carcinomaNational Cancer DatabaseProportional hazards regressionMultivariable logistic regressionPositive margin statusRetrospective database analysisParotid cancerMargin statusHazards regressionCancer DatabaseSurvival associationsDecreased oddsCystic carcinomaPatientsAdjuvant therapy in major salivary gland cancers: Analysis of 8580 patients in the National Cancer Database
Cheraghlou S, Kuo P, Mehra S, Agogo GO, Bhatia A, Husain ZA, Yarbrough WG, Burtness BA, Judson BL. Adjuvant therapy in major salivary gland cancers: Analysis of 8580 patients in the National Cancer Database. Head & Neck 2018, 40: 1343-1355. PMID: 29756412, DOI: 10.1002/hed.24984.Peer-Reviewed Original ResearchConceptsNational Cancer Data BaseLate-stage diseaseAdjuvant treatmentSalivary gland cancerAdverse featuresAdjuvant radiotherapyImproved survivalGland cancerMajor salivary gland cancerAddition of chemotherapyNational Cancer DatabaseAdjuvant therapySurvival benefitRetrospective studyCancer DatabaseImproved outcomesCancer casesPatientsChemotherapyDiseaseTreatmentRadiotherapySurvivalCancerTherapy
2015
Hospital readmission and 30‐day mortality after surgery for oral cavity cancer: Analysis of 21,681 cases
Luryi AL, Chen MM, Mehra S, Roman SA, Sosa JA, Judson BL. Hospital readmission and 30‐day mortality after surgery for oral cavity cancer: Analysis of 21,681 cases. Head & Neck 2015, 38: e221-e226. PMID: 25537226, DOI: 10.1002/hed.23973.Peer-Reviewed Original ResearchConceptsOral cavity squamous cell cancerSquamous cell cancerNational Cancer Data BaseHospital readmissionHigh-risk patientsUnplanned readmission rateComorbidity indexUnplanned readmissionNeck dissectionReadmission ratesOverall mortalityCell cancerStage T3Male sexRisk factorsRetrospective analysisAge 76Mortality rateReadmissionMortalityPatientsSurgeryT3T4Years
2014
Intrathyroidal Tumors Presenting with Extranodal Extension: What Are We Missing?
Clain JB, Mehra S, Scherl S, Dos Reis LL, Turk A, Wenig BM, Dewey EH, Urken ML. Intrathyroidal Tumors Presenting with Extranodal Extension: What Are We Missing? Endocrine Pathology 2014, 25: 385-389. PMID: 25325929, DOI: 10.1007/s12022-014-9340-9.Peer-Reviewed Original ResearchConceptsExtranodal extensionHistologic featuresIntrathyroidal tumorsLymphovascular invasionPerineural invasionLymphocytic thyroiditisLymph nodesPrimary tumorPsammoma bodiesNode-positive patientsPositive lymph nodesSubset of patientsFischer's exact testGroup A/BMann-Whitney testIntrathyroidal diseaseAggressive biologyPathologic featuresPoor prognosisTumor sizeThyroid cancerAggressive phenotypeExact testTumorsPatientsSubscapular system of flaps: An 8‐year experience with 105 patients
Gibber MJ, Clain JB, Jacobson AS, Buchbinder D, Scherl S, Zevallos JP, Mehra S, Urken ML. Subscapular system of flaps: An 8‐year experience with 105 patients. Head & Neck 2014, 37: 1200-1206. PMID: 24800735, DOI: 10.1002/hed.23738.Peer-Reviewed Original ResearchConceptsSubscapular systemFree flapRetrospective medical chart reviewExtensive surgical defectsMedical chart reviewOverall success rateDonor siteSoft tissue componentSoft tissue elementsLarge muscle flapsChart reviewEarly mobilizationAlternative donor siteMuscle flapAdvanced agePatientsNeck reconstructionSurgical defectsVital structuresFirst choiceMaxillary defectsFlapMandibular defectsSuccess rateNoninvasive Anaplastic Thyroid Carcinoma: Report of a Case and Literature Review
Dibelius G, Mehra S, Clain JB, Urken ML, Wenig BM. Noninvasive Anaplastic Thyroid Carcinoma: Report of a Case and Literature Review. Thyroid 2014, 24: 1319-1324. PMID: 24865498, DOI: 10.1089/thy.2013.0586.Peer-Reviewed Original ResearchConceptsAnaplastic thyroid carcinomaPositron emission tomography/American Thyroid Association guidelinesFine-needle aspiration biopsyManagement of patientsSeparate disease entityEmission tomography/Evidence of invasionSimilar casesUncommon thyroid malignancyAdjuvant therapyTotal thyroidectomyDistant metastasisFavorable prognosisPreoperative imagingTomography/Disease freeImmunohistochemical evaluationAssociation guidelinesDisease entityThyroid malignancyThyroid carcinomaAspiration biopsyThyroid tumorsPatientsExtrathyroidal Extension Predicts Extranodal Extension in Patients with Positive Lymph Nodes: An Important Association That May Affect Clinical Management
Clain JB, Scherl S, Dos Reis L, Turk A, Wenig BM, Mehra S, Karle WE, Urken ML. Extrathyroidal Extension Predicts Extranodal Extension in Patients with Positive Lymph Nodes: An Important Association That May Affect Clinical Management. Thyroid 2014, 24: 951-957. PMID: 24443878, DOI: 10.1089/thy.2013.0557.Peer-Reviewed Original ResearchConceptsExtranodal extensionLymph nodesPrimary tumorPresence of ENEAmerican Pathologists (CAP) protocolNode-positive patientsPositive lymph nodesRecurrent lymph nodesUpstaging of patientsMajority of patientsAggressive disease biologyLong-term survivalPresence of extensionCompletion thyroidectomyPositive nodesNodal metastasisRetrospective reviewHistologic featuresClinical managementDisease aggressivenessThyroid cancerT4 casesThyroid carcinomaHigh incidencePatientsTranstracheal approach to repair of a tracheo‐colonic fistula 44 years after colonic interposition
Mehra S, Scherl S, Lazarus C, Dewey E, Urken ML. Transtracheal approach to repair of a tracheo‐colonic fistula 44 years after colonic interposition. Head & Neck 2014, 36: e117-e120. PMID: 24375707, DOI: 10.1002/hed.23586.Peer-Reviewed Original ResearchConceptsTranstracheal approachColonic interpositionTraditional lateral approachSternocleidomastoid muscle flapTracheoesophageal fistula repairPrior esophagectomyUneventful recoveryRare pathologyCase reportFistula repairMuscle flapPrimary closureLateral approachDirect repairColon mucosaFistulaAlimentary tractPatientsInterpositionTracheaRepairEffective reconstitution