Featured Publications
Severe respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia
Gautam S, Cohen AJ, Stahl Y, Toro P, Young GM, Datta R, Yan X, Ristic NT, Bermejo SD, Sharma L, Restrepo M, Dela Cruz CS. Severe respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia. Thorax 2020, 75: 974-981. PMID: 32826284, DOI: 10.1136/thoraxjnl-2020-214896.Peer-Reviewed Original ResearchConceptsPure viral infectionBacterial coinfectionViral infectionInfluenza infectionSevere respiratory viral infectionsAbility of procalcitoninRetrospective cohort studyViral respiratory infectionsRespiratory viral infectionsMarker of severityRespiratory viral illnessSevere viral infectionsSpecificity of procalcitoninCharacteristic curve analysisCellular modelHigher procalcitoninProcalcitonin expressionElevated procalcitoninCohort studyViral illnessRespiratory infectionsAntibiotic administrationBacterial pneumoniaSevere diseaseProcalcitonin
2011
Type 2 inositol 1,4,5‐trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes
Kruglov EA, Gautam S, Guerra MT, Nathanson MH. Type 2 inositol 1,4,5‐trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes. Hepatology 2011, 54: 1790-1799. PMID: 21748767, PMCID: PMC3205211, DOI: 10.1002/hep.24548.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsATP Binding Cassette Transporter, Subfamily B, Member 11ATP-Binding Cassette TransportersBile Acids and SaltsBile CanaliculiCalciumCalcium SignalingCell Culture TechniquesCells, CulturedCholestasisCollagenDisease Models, AnimalHepatocytesInositol 1,4,5-Trisphosphate ReceptorsLipopolysaccharidesMaleProtein Processing, Post-TranslationalRatsRats, Sprague-DawleyConceptsBile salt secretionBSEP activityTrisphosphate receptorBile salt export pumpType II inositolSalt secretionPosttranslational regulationCell systemType 2 inositolCanalicular membraneCholesterol depletionIntrahepatic cholestasisConfocal immunofluorescenceFunctional polarityIntracellular calciumIsolated cell systemRat hepatocytesAnimal modelsSandwich cultureCollagen sandwich culturesPharmacologic inhibitionShort-term regulationCell membraneExport pumpSecretion