2015
Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis
Erson-Omay EZ, Çağlayan AO, Schultz N, Weinhold N, Omay SB, Özduman K, Köksal Y, Li J, Serin Harmancı A, Clark V, Carrión-Grant G, Baranoski J, Çağlar C, Barak T, Coşkun S, Baran B, Köse D, Sun J, Bakırcıoğlu M, Moliterno Günel J, Pamir MN, Mishra-Gorur K, Bilguvar K, Yasuno K, Vortmeyer A, Huttner AJ, Sander C, Günel M. Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis. Neuro-Oncology 2015, 17: 1356-1364. PMID: 25740784, PMCID: PMC4578578, DOI: 10.1093/neuonc/nov027.Peer-Reviewed Original ResearchConceptsHigh-grade gliomasSomatic POLE mutationsPOLE mutationsMalignant high-grade gliomasLonger progression-free survivalProgression-free survivalSomatic mutationsOverall survivalPediatric patientsBetter prognosisClinical featuresImproved prognosisClinical behaviorImmune cellsBizarre cellsAggressive formGlioblastoma multiformeDisease pathophysiologyMolecular subgroupsHomozygous germline mutationGermline mutationsPrognosisGlioma subtypesComprehensive genomic analysisDistinct subgroups
2014
Gamma Knife Radiosurgery for Cerebellopontine Angle Meningiomas: A Multicenter Study
Ding D, Starke RM, Kano H, Nakaji P, Barnett GH, Mathieu D, Chiang V, Omay SB, Hess J, McBride HL, Honea N, Lee JY, Rahmathulla G, Evanoff WA, Alonso-Basanta M, Lunsford LD, Sheehan JP. Gamma Knife Radiosurgery for Cerebellopontine Angle Meningiomas: A Multicenter Study. Neurosurgery 2014, 75: 398-408. PMID: 24991710, DOI: 10.1227/neu.0000000000000480.Peer-Reviewed Original ResearchConceptsGamma knife radiosurgeryCerebellopontine angle meningiomaNeurological deteriorationCPA meningiomasKnife radiosurgeryNorth American Gamma Knife ConsortiumSymptomatic adverse radiation effectsTumor progressionLower maximal dosePermanent neurological deteriorationCommon presenting symptomInitial surgical resectionMulticenter cohort studyOutcomes of patientsProgression-free survivalSignificant neurological morbidityMedian tumor volumeAdverse radiation effectsMultivariate regression analysisAdjuvant treatmentNeurological morbidityPresenting symptomCohort studyMost patientsSurgical resection