Modeling aging and cancer in the telomerase knockout mouse
Chang S. Modeling aging and cancer in the telomerase knockout mouse. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 2005, 576: 39-53. PMID: 15927211, DOI: 10.1016/j.mrfmmm.2004.08.020.Peer-Reviewed Original ResearchConceptsTelomere dysfunctionRole of telomeresTelomerase-null miceTelomerase knockout miceTelomerase-deficient miceOrganismal agingSomatic cellsMammalian organismsTight regulationCellular responsesTelomerase activityNull miceKnockout miceTelomeresMouse modelTelomeraseOrganismsMiceDeficient miceRegulationAgingCellsCancerModeling premature aging syndromes with the telomerase knockout mouse.
Chang S. Modeling premature aging syndromes with the telomerase knockout mouse. 2005, 5: 153-8. PMID: 15974868, DOI: 10.2174/1566524053586662.Peer-Reviewed Original ResearchConceptsTelomerase knockout miceMammalian agingGenomic instabilityDNA damage pathwayPremature aging syndromesCellular declineMolecular basisAging syndromesAging processDamage pathwayKnockout miceMolecular pathwaysShort telomeresHuman agingPrimate model systemMouse modelModel systemBiological mechanismsPhenotypePhysiological changesPathwayUnprecedented opportunityDeleterious effectsTelomeresMice