2001
Drosophila MyD88 is an adapter in the Toll signaling pathway
Horng T, Medzhitov R. Drosophila MyD88 is an adapter in the Toll signaling pathway. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 12654-12658. PMID: 11606776, PMCID: PMC60109, DOI: 10.1073/pnas.231471798.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, DifferentiationApoptosisCarrier ProteinsCaspasesDrosophila ProteinsFas-Associated Death Domain ProteinInsect ProteinsMembrane GlycoproteinsMyeloid Differentiation Factor 88Receptors, Cell SurfaceReceptors, ImmunologicToll-Like ReceptorsConceptsCell surface receptorsToll-1Death domain-containing proteinDomain-containing proteinsSurface receptorsDominant-negative versionDeath receptor-mediated pathwayDrosophila homologueS2 cellsApical caspasesEvolutionary ancestorInvertebrate cellsDMyD88Toll receptorAdult fliesDownstream componentsCaspase activationHuman MyD88Reporter geneInnate immune recognitionGenetic studiesAntifungal peptidesReceptor-mediated pathwayApoptosis inductionPelleRecognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou L, Holt A, Medzhitov R, Flavell R. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 2001, 413: 732-738. PMID: 11607032, DOI: 10.1038/35099560.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsAntigens, DifferentiationB-LymphocytesCell LineCells, CulturedCytokinesDrosophila ProteinsGalactosamineHumansInterferon Type ILymphocyte ActivationMacrophagesMembrane GlycoproteinsMiceMitogen-Activated Protein KinasesMolecular Sequence DataMyeloid Differentiation Factor 88NF-kappa BPoly I-CReceptors, Cell SurfaceReceptors, ImmunologicRNA, Double-StrandedSequence Homology, Amino AcidSignal TransductionToll-Like Receptor 3Toll-Like ReceptorsVirus DiseasesConceptsToll-like receptorsNF-κBI interferonInnate immune recognition receptorsToll-like receptor 3TLR3-deficient miceMolecular patternsPolyinosine-polycytidylic acidMitogen-activated proteinType I interferonMammalian TLR3Dendritic cellsInflammatory cytokinesImmune recognition receptorsViral infectionD-galactosamineReceptor 3MyD88Reduced productionReceptorsActivationMicrobial pathogensLethal effectsMost virusesAdaptor proteinTIRAP: an adapter molecule in the Toll signaling pathway
Horng T, Barton G, Medzhitov R. TIRAP: an adapter molecule in the Toll signaling pathway. Nature Immunology 2001, 2: 835-841. PMID: 11526399, DOI: 10.1038/ni0901-835.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsAntigens, DifferentiationCell DifferentiationCell LineCloning, MolecularCpG IslandsDendritic CellsDrosophila ProteinsEIF-2 KinaseHSP40 Heat-Shock ProteinsHumansLipopolysaccharidesMembrane GlycoproteinsMiceMolecular Sequence DataMutationMyeloid Differentiation Factor 88Receptors, Cell SurfaceReceptors, ImmunologicReceptors, Interleukin-1Sequence Homology, Amino AcidSignal TransductionToll-Like Receptor 4Toll-Like Receptor 9Toll-Like ReceptorsConceptsMammalian Toll-like receptorsProtein kinase PKRMitogen-activated protein kinaseToll-like receptorsKinase PKRAdapter proteinProtein kinaseMyD88-independent signalingPathways downstreamAdapter moleculeNF-κBSignaling pathwaysCellular responsesMicrobial metabolismAdapter protein MyD88MyD88-dependent signaling pathwaysProtein MyD88Absence of MyD88MyD88-deficient miceDendritic cell maturationCell maturationPathwayTLR4 ligationKinasePKR
2000
Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88
Schnare M, Holt† A, Takeda K, Akira S, Medzhitov R. Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Current Biology 2000, 10: 1139-1142. PMID: 10996797, DOI: 10.1016/s0960-9822(00)00700-4.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, DifferentiationB-LymphocytesCpG IslandsDendritic CellsDNADrosophila ProteinsEnzyme-Linked Immunosorbent AssayInterleukin-6Macrophages, PeritonealMembrane GlycoproteinsMiceMice, KnockoutMyeloid Differentiation Factor 88Receptors, Cell SurfaceReceptors, ImmunologicSignal TransductionToll-Like Receptor 2Toll-Like Receptor 4Toll-Like ReceptorsConceptsPathogen-associated molecular patternsPattern recognition receptorsInnate immune systemBacterial DNAFungal cell wallParticular sequence motifsParticular sequence contextCpG DNAToll-like receptorsAdaptor proteinSequence motifsAdaptor protein MyD88Signal transductionInnate immune recognitionToll familyCell wallSequence contextMolecular patternsDNAUnmethylated CpGRecognition receptorsProtein MyD88Immune systemPeptidoglycanDiverse group
1999
Innate immune induction of the adaptive immune response.
Medzhitov R, Janeway C. Innate immune induction of the adaptive immune response. Cold Spring Harbor Symposia On Quantitative Biology 1999, 64: 429-35. PMID: 11232318, DOI: 10.1101/sqb.1999.64.429.Peer-Reviewed Original ResearchAdaptation, PhysiologicalAdaptor Proteins, Signal TransducingAdjuvants, ImmunologicAnimalsAntigens, DifferentiationDrosophila ProteinsHumansImmunityInsect ProteinsMembrane GlycoproteinsMyeloid Differentiation Factor 88NF-kappa BProtein Serine-Threonine KinasesReceptors, Cell SurfaceReceptors, ImmunologicReceptors, Interleukin-1Receptors, Tumor Necrosis FactorSignal TransductionToll-Like Receptors
1998
MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways
Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S, Janeway C. MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways. Molecular Cell 1998, 2: 253-258. PMID: 9734363, DOI: 10.1016/s1097-2765(00)80136-7.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, DifferentiationDrosophilaDrosophila ProteinsHumansInterleukin-1 Receptor-Associated KinasesMembrane GlycoproteinsMembrane ProteinsMyeloid Differentiation Factor 88NF-kappa BProtein KinasesProteinsReceptors, Cell SurfaceReceptors, ImmunologicReceptors, Interleukin-1Signal TransductionTNF Receptor-Associated Factor 6Toll-Like ReceptorsTranscription Factor AP-1ConceptsIL-1R familyNF-kappaB activationNF-kappaB pathwayImmune response genesToll/IL-1R familyAP-1 activationImmune responseIL-1RTRAF6 proteinInnate immunityNF-kappaBMyD88Drosophila Toll proteinReceptor familyToll receptorAdaptor proteinSignaling pathwaysReceptorsActivationToll proteinRegulator moleculesResponse genesAdult DrosophilaPathwayProtein