ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway C, Ghosh S. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes & Development 1999, 13: 2059-2071. PMID: 10465784, PMCID: PMC316957, DOI: 10.1101/gad.13.16.2059.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsBiological EvolutionCell Line, TransformedCloning, MolecularDrosophilaDrosophila ProteinsEnzyme ActivationHumansInsect ProteinsMAP Kinase Kinase Kinase 1Membrane GlycoproteinsMiceMolecular Sequence DataNF-kappa BProtein Processing, Post-TranslationalProtein Serine-Threonine KinasesProteinsReceptors, Cell SurfaceReceptors, ImmunologicReceptors, Interleukin-1Saccharomyces cerevisiaeSignal TransductionTNF Receptor-Associated Factor 6Toll-Like ReceptorsInnate immune induction of the adaptive immune response.
Medzhitov R, Janeway C. Innate immune induction of the adaptive immune response. Cold Spring Harbor Symposia On Quantitative Biology 1999, 64: 429-35. PMID: 11232318, DOI: 10.1101/sqb.1999.64.429.Peer-Reviewed Original ResearchAdaptation, PhysiologicalAdaptor Proteins, Signal TransducingAdjuvants, ImmunologicAnimalsAntigens, DifferentiationDrosophila ProteinsHumansImmunityInsect ProteinsMembrane GlycoproteinsMyeloid Differentiation Factor 88NF-kappa BProtein Serine-Threonine KinasesReceptors, Cell SurfaceReceptors, ImmunologicReceptors, Interleukin-1Receptors, Tumor Necrosis FactorSignal TransductionToll-Like Receptors