2000
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley J, Tong L. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 2000, 408: 111-115. PMID: 11081518, DOI: 10.1038/35040600.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCloning, MolecularCrystallography, X-RayDrosophilaDrosophila ProteinsHumansMembrane GlycoproteinsMiceModels, MolecularMolecular Sequence DataPoint MutationProtein BindingProtein ConformationProtein Structure, TertiaryReceptors, Cell SurfaceReceptors, Interleukin-1Recombinant Fusion ProteinsStructure-Activity RelationshipToll-Like Receptor 1Toll-Like Receptor 2Toll-Like Receptor 4Toll-Like ReceptorsConceptsTIR domainSignal transductionFunctional studiesToll/interleukinSingle point mutationToll-like receptorsEquivalent residuesStructural basisReceptor domainInterleukin-1 receptorHuman TLR1Receptor signalingMutationsMyD88 adapterTransductionMurine TLR4Host immune responseAdaptive immunitySurface patchesResiduesReceptorsDomainMutantsMutagenesisYeast
1998
Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides
Chervonsky A, Medzhitov R, Denzin L, Barlow A, Rudensky A, Janeway C. Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 10094-10099. PMID: 9707606, PMCID: PMC21467, DOI: 10.1073/pnas.95.17.10094.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, MonoclonalAntigens, Differentiation, B-LymphocyteB-LymphocytesCarrier ProteinsCell MembraneDimerizationHistocompatibility Antigens Class IIMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMolecular Sequence DataProtein BindingProtein ConformationT-Lymphocytes
1992
The thrombin receptor: "All that is mine I carry with me".
Medzhitov R. The thrombin receptor: "All that is mine I carry with me". Биохимия 1992, 57: 1757-8. PMID: 1336983.Peer-Reviewed Original Research