Drosophila MyD88 is an adapter in the Toll signaling pathway
Horng T, Medzhitov R. Drosophila MyD88 is an adapter in the Toll signaling pathway. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 12654-12658. PMID: 11606776, PMCID: PMC60109, DOI: 10.1073/pnas.231471798.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, DifferentiationApoptosisCarrier ProteinsCaspasesDrosophila ProteinsFas-Associated Death Domain ProteinInsect ProteinsMembrane GlycoproteinsMyeloid Differentiation Factor 88Receptors, Cell SurfaceReceptors, ImmunologicToll-Like ReceptorsConceptsCell surface receptorsToll-1Death domain-containing proteinDomain-containing proteinsSurface receptorsDominant-negative versionDeath receptor-mediated pathwayDrosophila homologueS2 cellsApical caspasesEvolutionary ancestorInvertebrate cellsDMyD88Toll receptorAdult fliesDownstream componentsCaspase activationHuman MyD88Reporter geneInnate immune recognitionGenetic studiesAntifungal peptidesReceptor-mediated pathwayApoptosis inductionPelle