Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium
Frantz S, Kobzik L, Kim Y, Fukazawa R, Medzhitov R, Lee R, Kelly R. Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. Journal Of Clinical Investigation 1999, 104: 271-280. PMID: 10430608, PMCID: PMC408420, DOI: 10.1172/jci6709.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCD4 AntigensCells, CulturedCloning, MolecularCoronary VesselsDNA, ComplementaryDrosophila ProteinsGene Expression RegulationHeart FailureHeart VentriclesHumansImmunohistochemistryInterferon-gammaInterleukin-1LipopolysaccharidesMaleMembrane GlycoproteinsMiceMice, Inbred C57BLMolecular Sequence DataMyocardial InfarctionMyocardiumNF-kappa BNitric Oxide SynthaseNitric Oxide Synthase Type IIOrgan SpecificityRatsRats, Sprague-DawleyReceptors, Cell SurfaceRNA, MessengerToll-Like Receptor 4Toll-Like ReceptorsTranscription Factor AP-1ConceptsHuman Toll-like receptor 4Cardiac myocytesIL-1betaHuman myocardiumToll-like receptor 4Coronary microvascular endothelial cellsInnate immune response proteinsCytokine-inducible isoformTLR4 expression levelsNitric oxide synthaseMicrovascular endothelial cellsHearts of humansTLR4 stainingTLR4 expressionHeart failureTLR4 mRNAIschemic injuryReceptor 4Oxide synthaseImmune response proteinsControl myocardiumInnate immunityToll homologuesExperimental animalsMyocardium