Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley J, Tong L. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 2000, 408: 111-115. PMID: 11081518, DOI: 10.1038/35040600.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCloning, MolecularCrystallography, X-RayDrosophilaDrosophila ProteinsHumansMembrane GlycoproteinsMiceModels, MolecularMolecular Sequence DataPoint MutationProtein BindingProtein ConformationProtein Structure, TertiaryReceptors, Cell SurfaceReceptors, Interleukin-1Recombinant Fusion ProteinsStructure-Activity RelationshipToll-Like Receptor 1Toll-Like Receptor 2Toll-Like Receptor 4Toll-Like ReceptorsConceptsTIR domainSignal transductionFunctional studiesToll/interleukinSingle point mutationToll-like receptorsEquivalent residuesStructural basisReceptor domainInterleukin-1 receptorHuman TLR1Receptor signalingMutationsMyD88 adapterTransductionMurine TLR4Host immune responseAdaptive immunitySurface patchesResiduesReceptorsDomainMutantsMutagenesisYeast