2002
Toll-Like Receptors and Their Ligands
Barton G, Medzhitov R. Toll-Like Receptors and Their Ligands. Current Topics In Microbiology And Immunology 2002, 270: 81-92. PMID: 12467245, DOI: 10.1007/978-3-642-59430-4_5.Peer-Reviewed Original Research
2001
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou L, Holt A, Medzhitov R, Flavell R. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 2001, 413: 732-738. PMID: 11607032, DOI: 10.1038/35099560.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsAntigens, DifferentiationB-LymphocytesCell LineCells, CulturedCytokinesDrosophila ProteinsGalactosamineHumansInterferon Type ILymphocyte ActivationMacrophagesMembrane GlycoproteinsMiceMitogen-Activated Protein KinasesMolecular Sequence DataMyeloid Differentiation Factor 88NF-kappa BPoly I-CReceptors, Cell SurfaceReceptors, ImmunologicRNA, Double-StrandedSequence Homology, Amino AcidSignal TransductionToll-Like Receptor 3Toll-Like ReceptorsVirus DiseasesConceptsToll-like receptorsNF-κBI interferonInnate immune recognition receptorsToll-like receptor 3TLR3-deficient miceMolecular patternsPolyinosine-polycytidylic acidMitogen-activated proteinType I interferonMammalian TLR3Dendritic cellsInflammatory cytokinesImmune recognition receptorsViral infectionD-galactosamineReceptor 3MyD88Reduced productionReceptorsActivationMicrobial pathogensLethal effectsMost virusesAdaptor protein
2000
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley J, Tong L. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 2000, 408: 111-115. PMID: 11081518, DOI: 10.1038/35040600.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCloning, MolecularCrystallography, X-RayDrosophilaDrosophila ProteinsHumansMembrane GlycoproteinsMiceModels, MolecularMolecular Sequence DataPoint MutationProtein BindingProtein ConformationProtein Structure, TertiaryReceptors, Cell SurfaceReceptors, Interleukin-1Recombinant Fusion ProteinsStructure-Activity RelationshipToll-Like Receptor 1Toll-Like Receptor 2Toll-Like Receptor 4Toll-Like ReceptorsConceptsTIR domainSignal transductionFunctional studiesToll/interleukinSingle point mutationToll-like receptorsEquivalent residuesStructural basisReceptor domainInterleukin-1 receptorHuman TLR1Receptor signalingMutationsMyD88 adapterTransductionMurine TLR4Host immune responseAdaptive immunitySurface patchesResiduesReceptorsDomainMutantsMutagenesisYeastInnate immune recognition: mechanisms and pathways
Medzhitov R, Janeway C. Innate immune recognition: mechanisms and pathways. Immunological Reviews 2000, 173: 89-97. PMID: 10719670, DOI: 10.1034/j.1600-065x.2000.917309.x.Peer-Reviewed Original ResearchConceptsPattern recognition receptorsInnate immune systemMost multicellular organismsRecognition receptorsMulticellular organismsHost defenseInducible responsesImmune response genesResponse genesPathogen recognitionImmune systemMolecular patternsInfectious microbesAncient formPathwayReceptorsDefenseGenesMicrobesOrganismsMicroorganismsLarge groupPathogensExpressionPatterns
1999
Innate immunity: Lipoproteins take their Toll on the host
Janeway C, Medzhitov R. Innate immunity: Lipoproteins take their Toll on the host. Current Biology 1999, 9: r879-r882. PMID: 10607553, DOI: 10.1016/s0960-9822(00)80073-1.Peer-Reviewed Original ResearchThe Toll-receptor family and control of innate immunity
Kopp E, Medzhitov R. The Toll-receptor family and control of innate immunity. Current Opinion In Immunology 1999, 11: 13-18. PMID: 10047546, DOI: 10.1016/s0952-7915(99)80003-x.Peer-Reviewed Original ResearchConceptsInducible immune response genesToll receptor familyToll receptorTransduction pathwaysImmune response genesHost defense systemInnate immune recognitionMicrobial pathogensGermline-encoded receptorsNuclear factor-kappaBMolecular patternsDefense systemInnate immunityFactor-kappaBImmune recognitionPathwayReceptorsInsectsMammalsGenesPlantsPathogensExpressionKappaBFamily
1998
Innate immune recognition and control of adaptive immune responses
Medzhitov R, Janeway C. Innate immune recognition and control of adaptive immune responses. Seminars In Immunology 1998, 10: 351-353. PMID: 9799709, DOI: 10.1006/smim.1998.0136.Peer-Reviewed Original ResearchMyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways
Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S, Janeway C. MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways. Molecular Cell 1998, 2: 253-258. PMID: 9734363, DOI: 10.1016/s1097-2765(00)80136-7.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, DifferentiationDrosophilaDrosophila ProteinsHumansInterleukin-1 Receptor-Associated KinasesMembrane GlycoproteinsMembrane ProteinsMyeloid Differentiation Factor 88NF-kappa BProtein KinasesProteinsReceptors, Cell SurfaceReceptors, ImmunologicReceptors, Interleukin-1Signal TransductionTNF Receptor-Associated Factor 6Toll-Like ReceptorsTranscription Factor AP-1ConceptsIL-1R familyNF-kappaB activationNF-kappaB pathwayImmune response genesToll/IL-1R familyAP-1 activationImmune responseIL-1RTRAF6 proteinInnate immunityNF-kappaBMyD88Drosophila Toll proteinReceptor familyToll receptorAdaptor proteinSignaling pathwaysReceptorsActivationToll proteinRegulator moleculesResponse genesAdult DrosophilaPathwayProtein
1997
The orientation of a T cell receptor to its MHC class II:peptide ligands.
Hong S, Sant'Angelo D, Dittel B, Medzhitov R, Yoon S, Waterbury P, Janeway C. The orientation of a T cell receptor to its MHC class II:peptide ligands. The Journal Of Immunology 1997, 159: 4395-402. PMID: 9379037, DOI: 10.4049/jimmunol.159.9.4395.Peer-Reviewed Original ResearchConceptsMHC class II moleculesClass II moleculesComplementarity-determining region 1Self MHC class II moleculesCD4 T cellsMHC class IIT cell clonesMHC class II ligandsMHC class I.T cell receptorT cell linesCD4(-) TCRClass II ligandsD10 T cell cloneT cellsClass IICell receptorI-AkCell clonesClass I.ReceptorsCell linesTCRPresent study
1991
Evolution of regulatory proteins.
Medzhitov R. Evolution of regulatory proteins. Биохимия 1991, 56: 3-8. PMID: 1713794.Peer-Reviewed Original Research