2023
Immune sensing of food allergens promotes avoidance behaviour
Florsheim E, Bachtel N, Cullen J, Lima B, Godazgar M, Carvalho F, Chatain C, Zimmer M, Zhang C, Gautier G, Launay P, Wang A, Dietrich M, Medzhitov R. Immune sensing of food allergens promotes avoidance behaviour. Nature 2023, 620: 643-650. PMID: 37437602, PMCID: PMC10432274, DOI: 10.1038/s41586-023-06362-4.Peer-Reviewed Original ResearchConceptsMast cellsImmune systemBALB/c miceAllergen-specific IgEDifferentiation factor 15Behavioral modificationAllergen avoidanceAllergic sensitizationAllergic inflammationFood allergyTractus solitariusC miceCysteinyl leukotrienesParabrachial nucleusAllergen ingestionE antibodiesCentral amygdalaFactor 15Mouse modelFood allergensBrain areasImmune sensingAvoidance behaviorAversive stimuliGenetic background
2009
Learning Tolerance while Fighting Ignorance
Sansonetti P, Medzhitov R. Learning Tolerance while Fighting Ignorance. Journal Of End-to-End-testing 2009, 138: 416-420. DOI: 10.1016/s9999-9994(09)20455-7.Peer-Reviewed Original Research
2003
Toll-like receptors and their role in experimental models of microbial infection
Qureshi S, Medzhitov R. Toll-like receptors and their role in experimental models of microbial infection. Genes & Immunity 2003, 4: 87-94. PMID: 12618855, DOI: 10.1038/sj.gene.6363937.Peer-Reviewed Original ResearchConceptsImmune systemHost defenseToll-like receptor (TLR) familyExperimental modelTLR-deficient miceMicrobial infectionsAdaptive immune responsesToll-like receptorsEffective host defenseLimited human studiesInnate immune systemAdaptive immune systemPrompt recognitionImmune responseHuman studiesInnate immunityInfectious threatsInfectionReceptor familyAntimicrobial effectorsContainment measuresPathogen recognitionConstant surveillancePathogensActivation
2002
Toll-Like Receptors and Their Ligands
Barton G, Medzhitov R. Toll-Like Receptors and Their Ligands. Current Topics In Microbiology And Immunology 2002, 270: 81-92. PMID: 12467245, DOI: 10.1007/978-3-642-59430-4_5.Peer-Reviewed Original Research
2000
Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88
Schnare M, Holt† A, Takeda K, Akira S, Medzhitov R. Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Current Biology 2000, 10: 1139-1142. PMID: 10996797, DOI: 10.1016/s0960-9822(00)00700-4.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, DifferentiationB-LymphocytesCpG IslandsDendritic CellsDNADrosophila ProteinsEnzyme-Linked Immunosorbent AssayInterleukin-6Macrophages, PeritonealMembrane GlycoproteinsMiceMice, KnockoutMyeloid Differentiation Factor 88Receptors, Cell SurfaceReceptors, ImmunologicSignal TransductionToll-Like Receptor 2Toll-Like Receptor 4Toll-Like ReceptorsConceptsPathogen-associated molecular patternsPattern recognition receptorsInnate immune systemBacterial DNAFungal cell wallParticular sequence motifsParticular sequence contextCpG DNAToll-like receptorsAdaptor proteinSequence motifsAdaptor protein MyD88Signal transductionInnate immune recognitionToll familyCell wallSequence contextMolecular patternsDNAUnmethylated CpGRecognition receptorsProtein MyD88Immune systemPeptidoglycanDiverse groupInnate immune recognition: mechanisms and pathways
Medzhitov R, Janeway C. Innate immune recognition: mechanisms and pathways. Immunological Reviews 2000, 173: 89-97. PMID: 10719670, DOI: 10.1034/j.1600-065x.2000.917309.x.Peer-Reviewed Original ResearchConceptsPattern recognition receptorsInnate immune systemMost multicellular organismsRecognition receptorsMulticellular organismsHost defenseInducible responsesImmune response genesResponse genesPathogen recognitionImmune systemMolecular patternsInfectious microbesAncient formPathwayReceptorsDefenseGenesMicrobesOrganismsMicroorganismsLarge groupPathogensExpressionPatternsFly immunity: great expectations
Medzhitov R, Janeway C. Fly immunity: great expectations. Genome Biology 2000, 1: reviews106.1. PMID: 11104525, PMCID: PMC138838, DOI: 10.1186/gb-2000-1-1-reviews106.Peer-Reviewed Original ResearchConceptsDrosophila genome sequenceGenome sequenceImmune systemSequenceSimilarityImportant similarities
1998
Innate immune recognition and control of adaptive immune responses
Medzhitov R, Janeway C. Innate immune recognition and control of adaptive immune responses. Seminars In Immunology 1998, 10: 351-353. PMID: 9799709, DOI: 10.1006/smim.1998.0136.Peer-Reviewed Original ResearchAn ancient system of host defense
Medzhitov R, Janeway C. An ancient system of host defense. Current Opinion In Immunology 1998, 10: 12-15. PMID: 9523104, DOI: 10.1016/s0952-7915(98)80024-1.Peer-Reviewed Original Research
1996
Immunological tolerance: Danger – pathogen on the premises!
Janeway C, Goodnow C, Medzhitov R. Immunological tolerance: Danger – pathogen on the premises! Current Biology 1996, 6: 519-522. PMID: 8805259, DOI: 10.1016/s0960-9822(02)00531-6.Peer-Reviewed Original Research