2000
Innate immune recognition: mechanisms and pathways
Medzhitov R, Janeway C. Innate immune recognition: mechanisms and pathways. Immunological Reviews 2000, 173: 89-97. PMID: 10719670, DOI: 10.1034/j.1600-065x.2000.917309.x.Peer-Reviewed Original ResearchConceptsPattern recognition receptorsInnate immune systemMost multicellular organismsRecognition receptorsMulticellular organismsHost defenseInducible responsesImmune response genesResponse genesPathogen recognitionImmune systemMolecular patternsInfectious microbesAncient formPathwayReceptorsDefenseGenesMicrobesOrganismsMicroorganismsLarge groupPathogensExpressionPatterns
1999
The Toll-receptor family and control of innate immunity
Kopp E, Medzhitov R. The Toll-receptor family and control of innate immunity. Current Opinion In Immunology 1999, 11: 13-18. PMID: 10047546, DOI: 10.1016/s0952-7915(99)80003-x.Peer-Reviewed Original ResearchConceptsInducible immune response genesToll receptor familyToll receptorTransduction pathwaysImmune response genesHost defense systemInnate immune recognitionMicrobial pathogensGermline-encoded receptorsNuclear factor-kappaBMolecular patternsDefense systemInnate immunityFactor-kappaBImmune recognitionPathwayReceptorsInsectsMammalsGenesPlantsPathogensExpressionKappaBFamily