The orientation of a T cell receptor to its MHC class II:peptide ligands.
Hong S, Sant'Angelo D, Dittel B, Medzhitov R, Yoon S, Waterbury P, Janeway C. The orientation of a T cell receptor to its MHC class II:peptide ligands. The Journal Of Immunology 1997, 159: 4395-402. PMID: 9379037, DOI: 10.4049/jimmunol.159.9.4395.Peer-Reviewed Original ResearchConceptsMHC class II moleculesClass II moleculesComplementarity-determining region 1Self MHC class II moleculesCD4 T cellsMHC class IIT cell clonesMHC class II ligandsMHC class I.T cell receptorT cell linesCD4(-) TCRClass II ligandsD10 T cell cloneT cellsClass IICell receptorI-AkCell clonesClass I.ReceptorsCell linesTCRPresent studyA human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Medzhitov R, Preston-Hurlburt P, Janeway C. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388: 394-397. PMID: 9237759, DOI: 10.1038/41131.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsB7-1 AntigenCell LineCloning, MolecularDrosophilaDrosophila ProteinsHumansImmunityInsect ProteinsInterleukinsJurkat CellsMembrane GlycoproteinsMembrane ProteinsMiceMolecular Sequence DataMutationNF-kappa BReceptors, Cell SurfaceReceptors, ImmunologicRecombinant Fusion ProteinsSequence Homology, Amino AcidSignal TransductionT-LymphocytesToll-Like ReceptorsTransfectionConceptsDrosophila Toll proteinToll proteinCytoplasmic domainDrosophila TollHuman homologueLeucine-rich repeat domainNF-κB-controlled genesHuman cell linesRepeat domainActive mutantExtracellular domainNF-κBImmune responseInnate immune responseCo-stimulatory molecules B7.1Adaptive immune systemComponents of immunityInflammatory cytokines IL-1ProteinCell linesCo-stimulatory moleculesAntigen-presenting cellsAdaptive immune responsesNaive T cellsHomologues