2015
Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis
Pall PS, Hurwitz OE, King BA, LaMotte RH. Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis. Journal Of Pain 2015, 16: 741-749. PMID: 26002605, PMCID: PMC4522332, DOI: 10.1016/j.jpain.2015.04.009.Peer-Reviewed Original ResearchConceptsSquaric acid dibutyl esterAllergic contact dermatitisSpontaneous itchContact dermatitisNociceptive sensationsT cell-mediated inflammationExperimental modelPeripheral neural activityQuality of lifeInflammatory itchBAM8-22Skin inflammationHypersensitivity reactionsPain sensationAllergen resultsIntradermal injectionCommon conditionHealthy volunteersPotential treatmentItchPsychophysical measurementsInflammationVolar forearmDermatitisNeural activity
2012
A subpopulation of nociceptors specifically linked to itch
Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, LaMotte RH, Dong X. A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience 2012, 16: 174-182. PMID: 23263443, PMCID: PMC3557753, DOI: 10.1038/nn.3289.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAntirheumatic AgentsCalciumCapsaicinCells, CulturedChloroquineEpidermisGanglia, SpinalGene Expression RegulationGreen Fluorescent ProteinsHistamineHot TemperatureMaleMiceMice, Inbred C57BLMice, TransgenicMotor ActivityNerve FibersNerve Tissue ProteinsNociceptorsPain MeasurementPain ThresholdPatch-Clamp TechniquesPeptide FragmentsPlant LectinsProteinsProto-Oncogene Proteins c-fosPruritusReceptors, BombesinReceptors, G-Protein-CoupledRNA, UntranslatedRotarod Performance TestSensory Receptor CellsSensory System AgentsSpinal CordTRPV Cation Channels