2017
Molecular basis of tactile specialization in the duck bill
Schneider ER, Anderson EO, Mastrotto M, Matson JD, Schulz VP, Gallagher PG, LaMotte RH, Gracheva EO, Bagriantsev SN. Molecular basis of tactile specialization in the duck bill. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 13036-13041. PMID: 29109250, PMCID: PMC5724259, DOI: 10.1073/pnas.1708793114.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAvian ProteinsBeakChickensCloning, MolecularDucksEmbryo, NonmammalianGene ExpressionGenetic VectorsHEK293 CellsHumansIon ChannelsKineticsMechanoreceptorsMechanotransduction, CellularMicePatch-Clamp TechniquesRecombinant ProteinsRNA, Small InterferingSequence Homology, Amino AcidSpecies SpecificityTouchTouch PerceptionTrigeminal GanglionConceptsMolecular basisHeterologous expression systemSpecialist birdsMouse orthologPiezo2 ion channelsTactile specializationExpression systemDuck billMolecular characterizationIon channelsFeeding behaviorEdible matterPiezo2BirdsElectrophysiological characterizationSlow inactivation kineticsOrthologsVertebratesMechanoMechanotransductionKnockdownInactivation kineticsMurky watersHigh densityNeurons
2016
Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse
LaMotte RH. Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse. Advances In Experimental Medicine And Biology 2016, 904: 23-32. PMID: 26900060, PMCID: PMC4910628, DOI: 10.1007/978-94-017-7537-3_2.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisPersistent itchPathogenesis of ACDSquaric acid dibutyl esterPain-like behaviorsSmall-diameter neuronsPeripheral neural mechanismsPossible therapeutic targetInflammatory itchPruritic disordersCutaneous sitesChemokine CXCL10Excitatory responsesLocal inflammationReceptor CXCR3Contact dermatitisUnmyelinated axonsSpontaneous activityTherapeutic targetAnimal modelsPainSubsequent challengeTopical applicationItchMice
2015
Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis
Pall PS, Hurwitz OE, King BA, LaMotte RH. Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis. Journal Of Pain 2015, 16: 741-749. PMID: 26002605, PMCID: PMC4522332, DOI: 10.1016/j.jpain.2015.04.009.Peer-Reviewed Original ResearchConceptsSquaric acid dibutyl esterAllergic contact dermatitisSpontaneous itchContact dermatitisNociceptive sensationsT cell-mediated inflammationExperimental modelPeripheral neural activityQuality of lifeInflammatory itchBAM8-22Skin inflammationHypersensitivity reactionsPain sensationAllergen resultsIntradermal injectionCommon conditionHealthy volunteersPotential treatmentItchPsychophysical measurementsInflammationVolar forearmDermatitisNeural activity
2000
Softness Discrimination With a Tool
LaMotte R. Softness Discrimination With a Tool. Journal Of Neurophysiology 2000, 83: 1777-1786. PMID: 10758090, DOI: 10.1152/jn.2000.83.4.1777.Peer-Reviewed Original Research
1999
Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia
Brull S, Atanassoff P, Silverman D, Zhang J, Lamotte R. Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia. Somatosensory & Motor Research 1999, 16: 299-303. PMID: 10632027, DOI: 10.1080/08990229970366.Peer-Reviewed Original ResearchConceptsIntradermal injectionTactile allodyniaNociceptive primary afferent neuronsArea of allodyniaAreas of whealCapsaicin-induced allodyniaPrimary afferent neuronsCutaneous hyperalgesiaCutaneous allodyniaAfferent neuronsExperimental armControl armAllodyniaExperimental pruritusDysesthesiaeOpposite forearmVolar surfaceAlloknesisHuman volunteersItchHistamineHyperknesisHyperalgesiaInhibitory processesWhealEnhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia
Atanassoff P, Brull S, Zhang J, Greenquist K, Silverman D, Lamotte R. Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. Somatosensory & Motor Research 1999, 16: 291-298. PMID: 10632026, DOI: 10.1080/08990229970357.Peer-Reviewed Original ResearchConceptsAreas of dysesthesiaDuration of itchHistamine-evoked itchPrimary afferent neuronsAbnormal sensationAfferent neuronsCutaneous areaCentral inhibitionLocal anesthesiaEnhanced painControl armIntradermal injectionLocal anestheticsExperimental pruritusPainItchVolar forearmHistamineMechanical stimulationAfferentsHuman subjectsAnestheticsSkinPresent studySensation
1998
Raised Object on a Planar Surface Stroked Across the Fingerpad: Responses of Cutaneous Mechanoreceptors to Shape and Orientation
Lamotte R, Friedman R, Lu C, Khalsa P, Srinivasan M. Raised Object on a Planar Surface Stroked Across the Fingerpad: Responses of Cutaneous Mechanoreceptors to Shape and Orientation. Journal Of Neurophysiology 1998, 80: 2446-2466. PMID: 9819255, DOI: 10.1152/jn.1998.80.5.2446.Peer-Reviewed Original Research
1996
Reduction of Postburn Hyperalgesia after Local Injection of Ketorolac in Healthy Volunteers
Lundell J, Silverman D, Brull S, O'Connor T, Kitahata L, Collins J, LaMotte R. Reduction of Postburn Hyperalgesia after Local Injection of Ketorolac in Healthy Volunteers. Anesthesiology 1996, 84: 502-509. PMID: 8659776, DOI: 10.1097/00000542-199603000-00003.Peer-Reviewed Original ResearchConceptsHealthy volunteersEffect of pretreatmentNonsteroidal antiinflammatory drugsSystemic side effectsBradykinin-induced hyperalgesiaContact thermal stimulatorRepeated-measures analysisInflammatory painBradykinin injectionPain intensityPain thresholdAntiinflammatory drugsLocal injectionHyperalgesiaSide effectsKetorolacDrug AdministrationPainMild burnsThermal stimuliThermal stimulatorInjurySelective effectInjectionSaline
1995
Tactual discrimination of softness
Srinivasan M, LaMotte R. Tactual discrimination of softness. Journal Of Neurophysiology 1995, 73: 88-101. PMID: 7714593, DOI: 10.1152/jn.1995.73.1.88.Peer-Reviewed Original Research
1993
Cutaneous Mechanoreceptors of the Hand: Experimental Studies and Their Implications for Clinical Testing of Tactile Sensation
Greenspan J, LaMotte R. Cutaneous Mechanoreceptors of the Hand: Experimental Studies and Their Implications for Clinical Testing of Tactile Sensation. Journal Of Hand Therapy 1993, 6: 75-82. PMID: 8343885, DOI: 10.1016/s0894-1130(12)80287-0.Peer-Reviewed Original Research
1992
Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans.
Torebjörk H, Lundberg L, LaMotte R. Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans. The Journal Of Physiology 1992, 448: 765-780. PMID: 1593489, PMCID: PMC1176227, DOI: 10.1113/jphysiol.1992.sp019069.Peer-Reviewed Original ResearchConceptsMechanical hyperalgesiaCapsaicin injectionIntraneural microstimulationMechanoreceptive inputCapsaicin-induced secondary hyperalgesiaCutaneous innervation territoryArea of hyperalgesiaHealthy human subjectsSecondary hyperalgesiaAlgesic substancesLidocaine anesthesiaInnervation territoryIntense painIntradermal injectionUnmyelinated fibersHyperalgesiaMyelinated fibersC-fibersCentral changesPainAfferent signalsImpulse conductionSuprathreshold stimulationSkin areasTactile sensationPain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.
LaMotte R, Lundberg L, Torebjörk H. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. The Journal Of Physiology 1992, 448: 749-764. PMID: 1593488, PMCID: PMC1176226, DOI: 10.1113/jphysiol.1992.sp019068.Peer-Reviewed Original ResearchConceptsDuration of painMagnitude of painC-nociceptorsCapsaicin injectionMechanical hyperalgesiaIntradermal injectionTopical applicationReceptive fieldsC-mechanoheat nociceptorsEffects of capsaicinMean discharge rateCutaneous hyperalgesiaHyperalgesic areaUnchanged responsivenessBackground painAlgesic substancesPeroneal nerveNociceptor excitabilityNociceptor responsesPain thresholdMechanical stimuliNociceptor dischargeIntense painConcomitant painAwake humans
1991
Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms
LaMotte R, Shain C, Simone D, Tsai E. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. Journal Of Neurophysiology 1991, 66: 190-211. PMID: 1919666, DOI: 10.1152/jn.1991.66.1.190.Peer-Reviewed Original ResearchConceptsInjection of capsaicinMechanical hyperalgesiaNerve fibersInjection siteAlgesic substancesPrimary afferent nerve fibersArea of tendernessCapsaicin injection siteMicrograms of capsaicinNociceptive nerve fibersPeripheral neural activityArea of hyperalgesiaCutaneous nerve fibersAfferent nerve fibersMagnitude of painSingle intradermal injectionNeural activityArea of analgesiaSite of injuryLarger mean areaAnesthetized skinNeurogenic hyperalgesiaCutaneous anesthesiaIntradermal injectionPainful stimuliNeurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons
Simone D, Sorkin L, Oh U, Chung J, Owens C, LaMotte R, Willis W. Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons. Journal Of Neurophysiology 1991, 66: 228-246. PMID: 1919669, DOI: 10.1152/jn.1991.66.1.228.Peer-Reviewed Original ResearchConceptsSpinothalamic tract neuronsSTT neuronsWDR neuronsInjection siteHT neuronsNeurogenic hyperalgesiaTract neuronsIntradermal injectionPunctate stimuliCapsaicin injection siteMicrograms of capsaicinInjection of capsaicinCutaneous mechanical stimulationInjection of vehicleCentral neural correlatesSuprathreshold heat stimuliCutaneous hyperalgesiaWDR cellsCapsaicin injectionHeat painHyperalgesiaPainAnesthetized monkeysPreinjection valuesHeat stimuliPsychophysical Studies of the Itch Sensation and Itchy Skin (“Alloknesis”) Produced by Intracutaneous Injection of Histamine
Simone D, Alreja M, Lamotte R. Psychophysical Studies of the Itch Sensation and Itchy Skin (“Alloknesis”) Produced by Intracutaneous Injection of Histamine. Somatosensory & Motor Research 1991, 8: 271-279. PMID: 1767623, DOI: 10.3109/08990229109144750.Peer-Reviewed Original ResearchConceptsDuration of itchSubcutaneous injectionIntracutaneous injectionItchy skinArea of alloknesisSensation of itchMicrograms of histamineSkin temperatureItch sensationLocal anesthesiaAlloknesisMean latencyInjection siteMean maximum areaItchHuman volunteersHistamineVolar forearmDose-response functionInjectionNeural mechanismsSkinDoseDurationMicrograms
1990
Tactile detection of slip: surface microgeometry and peripheral neural codes
Srinivasan M, Whitehouse J, LaMotte R. Tactile detection of slip: surface microgeometry and peripheral neural codes. Journal Of Neurophysiology 1990, 63: 1323-1332. PMID: 2358880, DOI: 10.1152/jn.1990.63.6.1323.Peer-Reviewed Original Research
1988
Chapter 39 Psychophysical and neurophysiological studies of chemically induced cutaneous pain and itch The case of the missing nociceptor
LaMotte R. Chapter 39 Psychophysical and neurophysiological studies of chemically induced cutaneous pain and itch The case of the missing nociceptor. Progress In Brain Research 1988, 74: 331-335. PMID: 3187041, DOI: 10.1016/s0079-6123(08)63033-2.Peer-Reviewed Original ResearchConceptsCutaneous painInjection siteNeurophysiological studiesPeripheral nerve fibersSensation of painCapsaicin painInjection painMechanical hyperesthesiaHeat hyperalgesiaHeat nociceptorsIntradermal injectionCutaneous receptorsNerve fibersHistamine dihydrochloridePainNociceptorsCapsaicinGreater painItchAllodyniaHyperesthesiaFurther investigationCandidate mechanismInjectionSensation
1987
Hyperalgesia to heat after intradermal injection of capsaicin
Simone D, Ngeow J, Putterman G, LaMotte R. Hyperalgesia to heat after intradermal injection of capsaicin. Brain Research 1987, 418: 201-203. PMID: 3664271, DOI: 10.1016/0006-8993(87)90982-6.Peer-Reviewed Original ResearchThe Magnitude and Duration of Itch Produced by Intracutaneous Injections of Histamine
Simone D, Ngeow J, Whitehouse J, Becerra-Cabal L, Putterman G, Lamotte R. The Magnitude and Duration of Itch Produced by Intracutaneous Injections of Histamine. Somatosensory & Motor Research 1987, 5: 81-92. PMID: 3423533, DOI: 10.3109/07367228709144620.Peer-Reviewed Original ResearchConceptsDuration of itchArea of flareIntracutaneous injectionDose-dependent fashionHistamine doseMicrograms of histaminePeripheral neural mechanismsDose-dependent mannerIntracutaneous histamineItch magnitudeItch sensationLow doseItchHistamineVolar forearmDoseNeurophysiological studiesLonger durationMicrogramsMultiple injectionsInjectionNeural mechanismsDurationWeeksSubjects
1986
James Daniel Hardy (1904–1985). Tribute to a pioneer in pain psychophysics
LaMotte R. James Daniel Hardy (1904–1985). Tribute to a pioneer in pain psychophysics. Pain 1986, 27: 127-130. PMID: 3537920, DOI: 10.1016/0304-3959(86)90229-0.Peer-Reviewed Original Research