2015
Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice
Wang T, Hurwitz O, Shimada SG, Qu L, Fu K, Zhang P, Ma C, LaMotte RH. Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice. PLOS ONE 2015, 10: e0137512. PMID: 26356638, PMCID: PMC4565551, DOI: 10.1371/journal.pone.0137512.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsChronic DiseaseGanglia, SpinalHyperalgesiaMaleMice, Inbred C57BLNerve Compression SyndromesNociceptorsPainConceptsDorsal root gangliaPunctate mechanical stimuliSpontaneous activityChronic compressionCutaneous nociceptorsL3 dorsal root gangliaPost-operative day 2Evoked pain behaviorsPain-like behaviorsVon Frey filamentsDorsum of footUnoperated control miceMechanical stimuliCutaneous C nociceptorsBehavioral hyperalgesiaCCD surgeryIntraforaminal stenosisMechanical allodyniaRadicular painC-nociceptorsDRG neuronsPain behaviorControl miceEnhanced excitabilityControl neurons
2012
A subpopulation of nociceptors specifically linked to itch
Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, LaMotte RH, Dong X. A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience 2012, 16: 174-182. PMID: 23263443, PMCID: PMC3557753, DOI: 10.1038/nn.3289.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAntirheumatic AgentsCalciumCapsaicinCells, CulturedChloroquineEpidermisGanglia, SpinalGene Expression RegulationGreen Fluorescent ProteinsHistamineHot TemperatureMaleMiceMice, Inbred C57BLMice, TransgenicMotor ActivityNerve FibersNerve Tissue ProteinsNociceptorsPain MeasurementPain ThresholdPatch-Clamp TechniquesPeptide FragmentsPlant LectinsProteinsProto-Oncogene Proteins c-fosPruritusReceptors, BombesinReceptors, G-Protein-CoupledRNA, UntranslatedRotarod Performance TestSensory Receptor CellsSensory System AgentsSpinal CordTRPV Cation Channels
2006
MCP-1 Enhances Excitability of Nociceptive Neurons in Chronically Compressed Dorsal Root Ganglia
Sun J, Yang B, Donnelly D, Ma C, LaMotte R. MCP-1 Enhances Excitability of Nociceptive Neurons in Chronically Compressed Dorsal Root Ganglia. Journal Of Neurophysiology 2006, 96: 2189-2199. PMID: 16775210, DOI: 10.1152/jn.00222.2006.Peer-Reviewed Original ResearchConceptsMonocyte chemoattractant protein-1Dorsal root gangliaNociceptive neuronsRoot gangliaCompressed dorsal root ganglionIntact dorsal root gangliaSmall DRG neuronsProportion of neuronsChemoattractant protein-1Action potential widthNonselective cation conductanceMagnitude of depolarizationCCD neuronsChronic compressionDRG neuronsExcitatory effectsReceptor CCR2Nociceptive propertiesIntact gangliaNeuronal expressionInward currentsNeuronsCurrent clampGangliaReversal potential
1998
Raised Object on a Planar Surface Stroked Across the Fingerpad: Responses of Cutaneous Mechanoreceptors to Shape and Orientation
Lamotte R, Friedman R, Lu C, Khalsa P, Srinivasan M. Raised Object on a Planar Surface Stroked Across the Fingerpad: Responses of Cutaneous Mechanoreceptors to Shape and Orientation. Journal Of Neurophysiology 1998, 80: 2446-2466. PMID: 9819255, DOI: 10.1152/jn.1998.80.5.2446.Peer-Reviewed Original Research
1997
An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion
Zhang J, Song X, LaMotte R. An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion. Pain 1997, 72: 51-57. PMID: 9272787, DOI: 10.1016/s0304-3959(97)00013-4.Peer-Reviewed Original ResearchConceptsDorsal root gangliaNerve-injured ratsAdrenergic sensitivitySpontaneous activityUninjured nerveDRG cellsRoot gangliaSciatic nerveL5 dorsal root gangliaIntact dorsal root gangliaSelective alpha2-adrenergic agonistRat dorsal root gangliaAbnormal spontaneous activityInjured DRG neuronsSympathetic nervous systemAlpha2-adrenergic agonistDorsal root fibersIntact blood circulationCutaneous hyperalgesiaSpontaneous painDRG neuronsDorsal rootsSpontaneous dischargeC-fibersPeripheral axons
1989
Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin
Simone D, Baumann T, Collins J, LaMotte R. Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin. Brain Research 1989, 486: 185-189. PMID: 2720428, DOI: 10.1016/0006-8993(89)91293-6.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCapsaicinCatsFemaleMaleMechanoreceptorsPhysical StimulationSensory ThresholdsSpinal Cord
1982
Spatial properties of nociceptor sensitization following heat injury of the skin
Thalhammer J, LaMotte R. Spatial properties of nociceptor sensitization following heat injury of the skin. Brain Research 1982, 231: 257-265. PMID: 7055680, DOI: 10.1016/0006-8993(82)90364-x.Peer-Reviewed Original Research