2015
Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis
Pall PS, Hurwitz OE, King BA, LaMotte RH. Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis. Journal Of Pain 2015, 16: 741-749. PMID: 26002605, PMCID: PMC4522332, DOI: 10.1016/j.jpain.2015.04.009.Peer-Reviewed Original ResearchConceptsSquaric acid dibutyl esterAllergic contact dermatitisSpontaneous itchContact dermatitisNociceptive sensationsT cell-mediated inflammationExperimental modelPeripheral neural activityQuality of lifeInflammatory itchBAM8-22Skin inflammationHypersensitivity reactionsPain sensationAllergen resultsIntradermal injectionCommon conditionHealthy volunteersPotential treatmentItchPsychophysical measurementsInflammationVolar forearmDermatitisNeural activity
1998
Raised Object on a Planar Surface Stroked Across the Fingerpad: Responses of Cutaneous Mechanoreceptors to Shape and Orientation
Lamotte R, Friedman R, Lu C, Khalsa P, Srinivasan M. Raised Object on a Planar Surface Stroked Across the Fingerpad: Responses of Cutaneous Mechanoreceptors to Shape and Orientation. Journal Of Neurophysiology 1998, 80: 2446-2466. PMID: 9819255, DOI: 10.1152/jn.1998.80.5.2446.Peer-Reviewed Original Research
1991
Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms
LaMotte R, Shain C, Simone D, Tsai E. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. Journal Of Neurophysiology 1991, 66: 190-211. PMID: 1919666, DOI: 10.1152/jn.1991.66.1.190.Peer-Reviewed Original ResearchConceptsInjection of capsaicinMechanical hyperalgesiaNerve fibersInjection siteAlgesic substancesPrimary afferent nerve fibersArea of tendernessCapsaicin injection siteMicrograms of capsaicinNociceptive nerve fibersPeripheral neural activityArea of hyperalgesiaCutaneous nerve fibersAfferent nerve fibersMagnitude of painSingle intradermal injectionNeural activityArea of analgesiaSite of injuryLarger mean areaAnesthetized skinNeurogenic hyperalgesiaCutaneous anesthesiaIntradermal injectionPainful stimuliPsychophysical Studies of the Itch Sensation and Itchy Skin (“Alloknesis”) Produced by Intracutaneous Injection of Histamine
Simone D, Alreja M, Lamotte R. Psychophysical Studies of the Itch Sensation and Itchy Skin (“Alloknesis”) Produced by Intracutaneous Injection of Histamine. Somatosensory & Motor Research 1991, 8: 271-279. PMID: 1767623, DOI: 10.3109/08990229109144750.Peer-Reviewed Original ResearchConceptsDuration of itchSubcutaneous injectionIntracutaneous injectionItchy skinArea of alloknesisSensation of itchMicrograms of histamineSkin temperatureItch sensationLocal anesthesiaAlloknesisMean latencyInjection siteMean maximum areaItchHuman volunteersHistamineVolar forearmDose-response functionInjectionNeural mechanismsSkinDoseDurationMicrograms
1990
Tactile detection of slip: surface microgeometry and peripheral neural codes
Srinivasan M, Whitehouse J, LaMotte R. Tactile detection of slip: surface microgeometry and peripheral neural codes. Journal Of Neurophysiology 1990, 63: 1323-1332. PMID: 2358880, DOI: 10.1152/jn.1990.63.6.1323.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFingersHumansMacaca fascicularisMathematicsMotion PerceptionPeripheral NervesPsychophysicsSkinTouch
1988
Chapter 39 Psychophysical and neurophysiological studies of chemically induced cutaneous pain and itch The case of the missing nociceptor
LaMotte R. Chapter 39 Psychophysical and neurophysiological studies of chemically induced cutaneous pain and itch The case of the missing nociceptor. Progress In Brain Research 1988, 74: 331-335. PMID: 3187041, DOI: 10.1016/s0079-6123(08)63033-2.Peer-Reviewed Original ResearchConceptsCutaneous painInjection siteNeurophysiological studiesPeripheral nerve fibersSensation of painCapsaicin painInjection painMechanical hyperesthesiaHeat hyperalgesiaHeat nociceptorsIntradermal injectionCutaneous receptorsNerve fibersHistamine dihydrochloridePainNociceptorsCapsaicinGreater painItchAllodyniaHyperesthesiaFurther investigationCandidate mechanismInjectionSensation
1986
Tactile detection of a dot on a smooth surface: peripheral neural events
LaMotte R, Whitehouse J. Tactile detection of a dot on a smooth surface: peripheral neural events. Journal Of Neurophysiology 1986, 56: 1109-1128. PMID: 3097273, DOI: 10.1152/jn.1986.56.4.1109.Peer-Reviewed Original ResearchConceptsNumber of impulsesVon Frey filamentsPeripheral nerve fibersAnesthetized macaque monkeysReceptive fieldsFiber recordingsNerve fibersMacaque monkeysAction potentialsCertain stimulus conditionsNerve impulsesMagnitude of sensationTactile detectionSensory magnitudeStimulus conditionsResponse of RACapacity of humansSensory detectionNeural eventsMechanical eventsMonkeysSame stimuliSkinSensationRA
1983
Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: a comparison of neural events in monkey with sensory judgments in human
LaMotte R, Thalhammer J, Robinson C. Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: a comparison of neural events in monkey with sensory judgments in human. Journal Of Neurophysiology 1983, 50: 1-26. PMID: 6875640, DOI: 10.1152/jn.1983.50.1.1.Peer-Reviewed Original Research